摘要
目的:评价鸦胆子油乳、丝裂霉素和卡介苗3种药物行膀胱灌注预防浅表性膀胱癌术后复发的疗效和安全性。方法:2000-06-2006-05符合入选标准的178例浅表性膀胱癌(Ta-1,G1-2)患者随机分为鸦胆子油乳灌注组(A组,10%鸦胆子油乳60mL/次)、丝裂霉素灌注组(B组,20mg/次)和卡介苗灌注组(C组,120mg/次),术后1周开始定期灌注,共18次。行前瞻性、随机对照临床研究,密切随访2年,观察患者肿瘤复发情况及不良反应。结果:A、B、C组患者术后2年肿瘤复发率分别为14.04%(8/57)、34.85%(23/66)和18.18%(10/55),A组肿瘤复发率明显低于B组(χ2=6.17,P<0.05);A组患者的无病间期与B组差异有统计学意义,F=7.03,P<0.05。A、B、C三组不良反应发生率分别为12.28%(7/57)、43.94%(29/66)和83.64%(46/55),A组患者不良反应发生率显著低于B、C两组(χ2AB=15.72,P<0.01;χ2AC=55.34,P<0.01)。结论:鸦胆子油乳膀胱灌注对预防浅表性膀胱癌术后复发有良好疗效,不良反应发生率低,是一种值得推广的治疗方法。
OBJECTIVE：To study the effect of brucea javanica oil emulsion,mitomycin and Bacille Calmette-Guerinin （BCG） on preventing the recurrence of postoperative intravesical therapy in superficial bladder tumor.METHODS：A total of 178 postoperative patients with stages Ta to T1 primary superficial,grades 1 or 2 bladder carcinoma were randomly assigned into 3 groups.Group A received instillation of 60 mL 10% brucea javanica oil,Group B received instillation of 20 mg mitomycin,and Group C received instillation of 120 mg BCG after 1 weeek of the operation.The patients were followed up for clinical,analytical and cystoscopic evaluations for 2 years.The tumor recurrence rates and side effects after the treatment were evaluated.RESULTS：The recurrence rates were 14.04%（8/57）,34.85%（23/66） and 18.18%（10/55） of Group A,B and C 2 years after operation,respectively.The recurrence rate of Group A was lower than that of Group B （χ^2=6.17,P〈0.05）.The disease free intervals of Group A had a significant difference with Group B （F=7.03,P〈0.05）.The side effect of Group A （12.28%） was lower than that of Group B （43.94%） and Group C （83.64%） （χ^2AB=15.72,P〈0.01;χ^2AC=55.34,P〈0.01）.CONCLUSION：Instillation of 10% brucea javanica oil emulsion after operation is safe and effective in preventing superficial bladder tumor recurrence.
出处
《中华肿瘤防治杂志》
CAS
2010年第8期622-624,共3页
Chinese Journal of Cancer Prevention and Treatment
关键词
膀胱肿瘤/药物疗法
灌注
局部
肿瘤复发
局部
bladder neoplasms/drug therapy
perfusion
regional
neoplasm recurrence
local
