摘要
通过精子畸形试验、微核试验及姐妹染色单体交换试验，进行了汉防己甲素对小鼠遗传毒性的实验研究，结果表明：汉防己甲素组的小鼠精子畸形率及小鼠骨髓细胞微核率显著增高，且与微核率之间存在剂量—反应关系。但小鼠姊妹染色单体交换频率的改变不显著，表明该药对实验动物具有遗传毒性。
The genetic toxicity of tetrandrine on mice was studied by sperm deformity test,marrow micronucleus test and sister chromatid exchange. The results showed that the rate of spermatic deformity and marrow cells micronucleus in mouse was increased significantly in growps treated with tetrandrine, and there was dose response relationship, but the change of the frequencies of sister chromatid exchanges was not obvious. It is concluded that tetrandrine has genetic toxicity to experimental animal.
出处
《癌变．畸变．突变》
CAS
CSCD
1999年第2期94-95,共2页
Carcinogenesis,Teratogenesis & Mutagenesis
关键词
汉防己甲素
微核
SCE
精子畸形
遗传毒性
tetrandrine
microncleus
sister chromatid exchange
sperm diformity
