摘要
目的探讨FOXO1A及FLASH在胃癌组织中的表达及其临床意义。方法应用免疫组织化学方法 ,对68例胃癌切除标本中FOXO1A及FLASH的表达情况进行检测。分析两种基因表达与胃癌临床病理参数的关系。结果在胃癌组织中,FOXO1A及FLASH的阳性表达率分别为73.53%(50/68)和77.94%(53/68)。FLASH的表达与患者的年龄、性别、肿块的位置、大小、淋巴结转移、浸润深度等均无关,只与肿瘤的分化程度呈负相关。FOXO1A的表达除与肿瘤分化程度呈负相关之外,还与患者性别相关。配对卡方分析显示FLASH和FOXO1A之间并无显著关联。在癌旁组织中,两种基因的表达主要在上皮内肿瘤病变区,在正常黏膜中不表达或呈极弱表达。结论 FOXO1A、FLASH在高分化胃癌中的表达属高频发事件,它们可能在胃癌的肿瘤发生和发展过程中起到了一定的作用。两基因表达在统计学上并未有显著的关系。
Objective To study the significance of FOXO1A, FLASH expression and analyzed their relationship with tumor clinicopathological features. Methods FOXO1A and FLASH expression were examined by immunohistochemical staining method in 68 cases of human gastric cancer compared with human normal gastric tissue. Further analysis was performed to make sure their relationship with some tumor clinicopathological features. Results In gastric carcinomas, the expression of FOXO1A, FLASH were 73.53%（50/68） and 77.94%（53/68） respectively. There were no significant associations between FLASH and age, tumor location, tumor size, depth of penetration or lymphatic metastasis. Besides grading, the expression of FOXO1A was related to gender too and higher in male. There was no significant correlation between the expression of FOXO1A and FLASH. In intraepithelial neoplasia gastric mucosa, the expression of FOXO1A and FLASH presents intensive positively. Their expression in epithelial cells of normal gastric mucosa was shown as no or very weak intensity.Conclusion In conclusion, our results showed that the expression of FOXO1A and FLASH is a frequent event in highly differentiated gastric carcinoma, and may play important role in tumorigenesis and tumor development. There was no significant correlation between the expression of FOXO1A and FLASH.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2010年第6期675-678,共4页
Cancer Research on Prevention and Treatment
