西宁地区冠心病患者血清C-反应蛋白、同型半胱氨酸及叶酸水平的检测分析被引量：1

下载PDF

导出

摘要目的:探讨C-反应蛋白(CRP)、同型半胱氨酸(HCY)、叶酸(FA)联合检测在冠心病(CHD)诊断中的临床价值。方法:对临床确诊的80例心肌梗死患者、32例稳定型心绞痛患者、40例不稳定型心绞痛患者和100例正常健康体检者同时进行C-反应蛋白(CRP)、同型半胱氨酸(HCY)、叶酸(FA)及维生素B12(VitB12)水平的检测,并将检测结果与冠心病进行相关性分析。结果:心肌梗死(AMI)组、心绞痛组与正常对照组比较,血清CRP、HCY水平显著增高,差异有显著性(P<0.01)。而FA水平则显著低于健康对照组,差异有显著性(P<0.01)。结论:高CRP、HCY及FA、VitB12的缺乏是CHD的独立危险因素,CYP、HCY、FA联合检测可提高诊断CHD的特异性和敏感性。

作者张新云

机构地区青海红十字医院检验科

出处《青海医药杂志》 2010年第4期50-51,共2页 Qinghai Medical Journal

关键词 C-反应蛋白同型半胱氨酸叶酸冠心病

分类号 R541.4 [医药卫生—心血管疾病] R446.1 [医药卫生—内科学]

引文网络
相关文献

参考文献7

1Ridker P M. High - sensitivity C - reactive Potenitid adjunet for global risr assessment in the primary Prevention of cardiovascular disease. Circulation, 2001, 103 ( 13 ) : 1 813 - 1 818. 被引量：1
2Refsum H , Ueland P M , Nygard O , et al . Homocysteine and cardiovascular disease . Annu Rev Med ,1998 ,49 :31. 被引量：1
3Cananeo M. Hyperhomocysteinemia, atherosclerosis and thrombosis. Thromb Haemost, 1999,81 (2) : 165. 被引量：1
4李丹,敬华,王晓非,杨晋德,陈兴明,郭海港.应用ROC曲线评价C反应蛋白比值预测不稳定心绞痛急性发作的价值[J].临床检验杂志,2005,23(3):192-193. 被引量：3
5Clarker , Lewingtons . Homoeysteine and coronary" heart diseases . Semin Vase Med,2002,2(4) :391. 被引量：1
6Anker GB, Resum H, Ueland PM, et al . Influence of aromatase inhibitors on plasma total homocysteine in post menopausal breast cancer patients . Clan Chem, 1999,45:252. 被引量：1
7张春丽,王荣福,姜宁,高炜.血液中叶酸、维生素B_(12)水平与冠状动脉病变的关系及其机理探讨[J].标记免疫分析与临床,2006,13(3):137-140. 被引量：6

二级参考文献19

1Cairns J A, Fantus I G, Klassen G A. Unstable angina pectoris [J].Am Heart J, 1976,92 ( 3 ) :373-386. 被引量：1
2Gottlieb S O. The prognostic importance of asymptomatic ischemic episodes in patients with unstable angina pectoris[ J]. Herz, 1987,12(5) :336-340. 被引量：1
3Abbate A, Biondi-Zoccai G G, Brugaletta S, et al. C-reactive protein and other inflammatory biomarkers as predictors of outcome following acute coronary syndromes [ J ]. Semin Vasc Med,2003,3 (4) :375 -384. 被引量：1
4Pearson T A, Mensah G A, Alexander R W, et al. Markers of inflammation and cardiovascular disease [ J ]. Circulation, 2003,107(3) :499-511. 被引量：1
5Clarke R,Lewington S.Homocysteine and coronary heart disease[J].Semin Vasc Med,2002,2(4):391-399. 被引量：1
6Fowler B.Homocysteine-an independent risk factor for cardiovascular and thrombotic diseases[J].Ther Umsch,2005,62(9):641-646. 被引量：1
7Naumovski N,Roach P D,Blades B,et al.The relationship between plasma homocysteine,red cell folate and plasma vitamin B12 in a sample of the New South Wales Central Coast population[J].Asia Pac J Clin Nutr,2003; 12 (Suppl):S24. 被引量：1
8Lee B J,Lin P T,Liaw Y P,et al.Homocysteine and risk of coronary artery disease:Folate is the important determinant of plasma homocysteine concentration[J].Nutrition,2003,19(7-8):577-583. 被引量：1
9Voutilainen S,Lakka T A,Porkkala-Sarataho,E,et al.Low serum folate concentrations are associated with an excess incidence of acute coronary events:the Kuopio Ischaemic Heart Disease Risk Factor Study[J].Eur J Clin Nutr,2000,54(5):424-428. 被引量：1
10Fairfield K M,Fletcher R H.Vitamins for chronic disease prevention in adults:scientific review[J].JAMA.2002,287(23):3116-3126. 被引量：1