摘要
目的采用受试者操作特性(ROC)曲线评价C反应蛋白(CRP)预测心绞痛急性发作的价值。方法应用增强胶乳透射比浊法每日检测78例不稳定心绞痛(UA)患者的血清CRP,根据发作前24h及发作前24～48h患者CRP水平与其自身缓解期平均水平的比值描绘ROC曲线并进行分析。结果UA患者发作前24h及发作前24～48h该比值分别为2.05±0.33和1.41±0.27,ROC曲线下面积分别为0.981和0.894。以比值>1.630为临界值预测24h内心绞痛急性发作的敏感性为91.0%、特异性96.3%,阳性似然比24.6、阴性似然比0.09。结论检测血清CRP水平/缓解期水平的比值能够有效地预测UA患者心绞痛急性发作。
Objective To evaluate hypersensitive C reaction protein (hs-CRP) as aprognostic marker for acute onset of unstable angina pectoris (UA) by using receiver operating characteristic (ROC) analysis.Methods hs-CRP levels in serial serum samples from 78 unstable angina (UA) patients in either onset or remission period were detected by particle-enhanced immunoturbidimetric assay everyday.The ratios of hs-CRP level during the period of the 24 hours and the 24-48 hours before onset to those in remission period were calculated.ROC curve was analyzed according to the ratio of hs-CRP levels of different periods.Results The ratio of hs-CRP levels was 2.05±0.33 in the 24 hours and 1.41±0.27 in the 24-48 hours before onset,and the area under curve (AUC) was 0.981 and 0.894 respectively.When a more than 1.630 of ratio was used as cutoff value,the sensitivity for prediction of angina pectoris onset was 91.0%,the specificity was 96.3%,positive likelihood ratio was 24.6,and negative likelihood ratio was 0.09.Conclusions Detection of serum hs-CRP level in unstable angina patients and calculation of the ratio to basic level should be an effective method for prediction of angina pectoris onset.
出处
《临床检验杂志》
CAS
CSCD
北大核心
2005年第3期192-193,共2页
Chinese Journal of Clinical Laboratory Science
