摘要
目的研究神经性厌食(AN)患者的事件相关电位P300特点。方法应用Nicolet Bravo脑电生理仪,采用纯音"Oddball"刺激诱发模式,对43例AN患者和34名健康对照进行认知性电位P300检测。结果 AN组P300中靶P3的潜伏期[(297.8±29.3)ms]长于健康对照组[(285.6±19.7)ms],差异有统计学意义(t=2.19,P=0.03);AN组靶P3波幅为(6.5±3.4)μV,低于健康对照组(9.8±3.2)μV,差异有统计学意义(t=4.33,P<0.01)。2组的靶P2、靶N2及非靶P2的潜伏期、波幅均无统计学差异。结论 AN患者的P300靶P3潜伏期延长、波幅降低。
Objective：To investigate the characteristics of P300 in patients with anorexia nervosa （AN）.Methods：P300 were recorded in 43 AN patients and 34 healthy controls by the standard oddball paradigm presented with auditory double clicks stimuli,using Nicolet Bravo instrument.Results：Compared with control group,AN group showed significantly prolonged latency of target P3 （t=2.19,P=0.03） and significantly decreased amplitude of target P3 （t=4.33,P0.01）.There were no significant difference in the latencies and amplitudes of target P2,target N2 and non-target P2 between the two groups.Conclusion：AN Patients were characterized with prolonged latency and decreased amplitude of target P3 in the P300,supporting the hypothesis that they might have cognitive impairment.
出处
《上海精神医学》
2010年第3期144-146,共3页
Shanghai Archives of Psychiatry
基金
上海市卫生局青年科研基金(034Y26)
