摘要
目的:探讨缺氧、缺血性脑病(HIE)患儿血清NSE、TNF-α和IL-6水平的变化及临床意义。方法:应用放射免疫分析和酶联法对30例HIE患儿进行血清NSE、TNF-α和IL-6测定,并与30名正常健康儿做比较。结果:HIE患儿血清NSE、TNF-α和IL-6水平均非常显著地高于正常儿组(P<0.01)。相关分析显示,血清NSE、TNF-α和IL-6呈明显的正相关(r=0.5812、0.6014,P<0.01)。结论:检测HIE患儿血清NSE、TNF-α和IL-6水平的变化对了解病情、观察预后具有重要的临床价值。
Objective To study the clinical significance of changes of serum NSE,TNF-α and IL-6 levels in neonates with hypoxic ischemic encephalopathy.Methods Serum NSE（with ELISA）and TNF-α,IL-6（with RIA）levels were measured in 30 neonates with hypoxic ischemic encephalopaphy and 30 controls.Results Serum NSE,TNF-α and IL-6 levels were significantly higher in neonates with hypoxic-ischemic encephalopathy than those in controls（P0.01）.Serum NSE levels were positively correlated with those of TNF-α,IL-6（r=0.5812、0.6014,P0.01）.Conclusion Serum NSE,TNF-α and IL-6 levels wree closely related to the diseases process of hypoxic-ischemic encephalopathy.
出处
《放射免疫学杂志》
CAS
2010年第3期275-277,共3页
Journal of Radioimmanology
关键词
HIE
神经元特异性烯醇化酶
肿瘤坏死因子-α
白细胞介素-6
hypoxic-ischemic encephalopathy（HIE）
neuron specific enolase（NSE）
tumor-necrosis factor-α（TNF-α）
interleukin-6（IL-6）
