摘要
SK channels are small conductance calcium-activated potassium channels that are widely expressed in different neurons with distinct subtypes.They play an important role in modulating synaptic plasticity,dopaminergic neurotransmission, and learning and memory.The present review was mainly focused on the recent findings on the contradictory roles of SK channels in modulating dopaminergic neurons in substantia nigra and in the pathogenesis of Parkinson＇s disease （PD） . Besides,whether modulation of SK channels could be a potential target for PD treatment was also discussed.
小电导钙激活钾通道也即SK通道,其广泛表达于不同亚型的神经元中,在调节突触可塑性、学习与记忆和多巴胺能神经传递过程中发挥重要作用。本文重点讨论了SK通道调节黑质多巴胺能神经元的作用及其在帕金森病发病机制中的争议性角色,并对调控SK通道是否可成为一种新的治疗帕金森病的方法进行了探讨。
基金
supported by the National Basic Research Development Program of China(No.2006CB500706)
the National Natural Science Foundation of China(No.30700251,30872729,30971031)
Shanghai Key Discipline Program(No.S30202)
the Program for Out-standing Medical Academic Leader(No.LJ 06003)
