摘要
目的考察不同品种枳实对心血管和呼吸系统的作用差异。方法采用麻醉大鼠,经十二指肠给予不同产地枳实提取物,给药剂量为4.2、2.1g原药材/kg,给药后连续4h观察大鼠血压、呼吸及心电图情况。结果与对照组比较,酸橙大剂量组及甜橙大、小剂量组动物呼吸幅度于药后20min一过性升高,后均恢复正常,各实验组之间差异均无统计学意义;实验期间未观察到枳实对心电的影响,各实验组之间差异无统计学意义;酸橙对血压的影响较显著,与对照组比较,酸橙大剂量组动物收缩压、舒张压及平均血压的降低于药后40、60、80min差异均有统计学意义,小剂量组于药后60min也有显著差异,提示酸橙确有一定的降压作用,作用持续时间可达2h以上。甜橙对血压的影响并不明显,酸橙组与甜橙组比较有显著差异。结论我国药典规定的两种枳实对呼吸系统有一过性的兴奋作用,对心脏的直接作用不明显,但酸橙的降压作用明显优于甜橙,在临床使用中应给予注意。
Objective To investigate the different effects of 2 species of Fructus aurantii immaturus on cardiovascular and respiratory system. Methods The extract of 2 species of Fructus aurantii immaturus were administered to anesthetized rats by duodenum and the dosages were 4.2, 2.1 g crude drug/kg respectively. After administration, a continuous observation of blood pressure, respiration and ECG effects for 4 hours were performed. Results Compared with the control group, both of Citrus aurantium and Citrus sinesis exerted a transient increase to respiration rate after 20 min administration. No significant impact was observed during the experiment period on the ECG. The influence of Citrus aurantium on blood pressure was more significant. Compared with the control group, the effects of SBP, DBP and MBP reduced was observed in high-dose group of Citrus aurantium after 40, 60, 80 min administration, and so in low-dose group of Citrus aurantium after 60 rain. The impact duration was up to 2 hours or more. However, the antihypertensive effect of Citrus sinesis was not obvious. And the blood pressure lowering effect of Citrus aurantium was superior to Citrus sinesis. Conclusion The 2 species of Fructus aurantii immaturus exert a transient excitatory effect on respiratory system. And the direct effect of them on heart is not obvious. The blood pressure lowering effect of Citrus aurantium is superior to Citrus sinesis. The attention should be given in the clinical usage of Fructus aurantii immaturus.
出处
《中国中医药信息杂志》
CAS
CSCD
2010年第6期41-43,共3页
Chinese Journal of Information on Traditional Chinese Medicine
基金
国家自然科学基金(30772726)
北京市自然科学基金(7072052)
关键词
枳实
心血管系统
呼吸系统
大鼠
Fructus aurantii immaturus
cardiovascular system
respiratory system
rat
