摘要
干扰素是一类多功能细胞因子,是由哺乳动物细胞受到适宜刺激产生的一种微量的、具高度生物学活性的蛋白质,具有抵抗病毒感染、抑制肿瘤生长和调节机体免疫功能的作用。干扰素α血浆半衰期短而丙型和乙型肝炎治疗周期长,影响了患者的依从性。目前延长蛋白药物半衰期的方法主要有化学修饰、蛋白融合、定点突变技术联合和改造药物制剂释放系统,随着又一新型长效干扰素ZALBIN即将上市,长效干扰素再次成为医药行业的聚焦点。现针对干扰素α长效制剂中的最新研究进展进行综述。
Interferons are a class of cytokines that play key roles in the regulation of cell growth and differentiation via activation of a cascade of intracellular pathways and represented the functions of antiviral,immunomodulatory,and antiproliferative effects,which are synthesized and secreted by somatic cells of all mammalian species.Interferon alpha（IFN-α）are used in clinic to treat a variety of viral diseases and cancers.Howerver,the short circulating half-life of IFN-α necessitates frequent administration to patients which limits the broader usage.The methods of prolonging the half-life of protein drug in common use are chemical modification,albumin fusion technology,analog construction and combination with drug delivery system.Herein the method of prolonging the half-life of IFN-α in the above-mentioned of the latest research methods were reviewed.
出处
《中国生物工程杂志》
CAS
CSCD
北大核心
2010年第5期122-127,共6页
China Biotechnology
