摘要
目的:探讨核因子(NF)-κBp65蛋白在不同子宫内膜组织中的表达及其与雌激素受体(ER)α蛋白之间的关系。方法:应用免疫组织化学二步法检测10例正常子宫内膜、60例子宫内膜增生症、20例子宫内膜样腺癌中NF-κBp65蛋白、ERα蛋白的表达,并分析NF-κBp65和ERα蛋白在3组中的表达情况。结果:在正常子宫内膜、子宫内膜增生症及子宫内膜样腺癌中NF-κBp65蛋白中位表达率分别为0、0.47%及9.13%,ERα蛋白平均表达率分别为5.25%、49.97%及35.01%,差别均有统计学意义(P<0.05或P<0.01)。在子宫内膜增生类型为单纯性增生、复杂性增生及非典型增生的组织中,NF-κBp65蛋白中位表达率分别为0、1.27%及3.49%,差别均有统计学意义;ERα蛋白平均表达率分别为60.81%、52.30%及36.81%,单纯性增生组与非典型增生组、复杂性增生组与非典型增生组之间差别均有统计学意义(P<0.05或P<0.01)。在内膜样腺癌中,NF-κBp65与ERα表达呈负相关(r=-0.491,P=0.028)。结论:NF-κBp65蛋白与ERα蛋白在子宫内膜增生症及子宫内膜样腺癌组织中表达异常,可能促进了子宫内膜样腺癌的形成和进展。
Objective：To investigate the expression of nuclear factor kappa B （NF-κB） p65 in different tissues of human endometrium and its relationship with estrogen receptor （ER） α.Methods： The expressions of NF-κB p65 and ERα were detected with immunohistochemical SP methods in 10 cases of normal endometrium,60 cases of endometrial hyperplasia and 20 cases of endometrioid adenocarcinoma.Results：It was found that the expression of NF-κB p65 gradually raised in normal endometrium（0）,endometrial hyperplasia （0.47%） and endometrioid adenocarcinoma（9.13%）,with significant differences between these 3 groups （P 0.05 or P 0.01）.The expression of ERα gradually reduced in 5.25%,4.97% and 35.01%,with significant differences between them （P 0.05 or P 0.01）.The expressions of NF-κB p65 and Era in endometrial hyperplasia were 0 and 60.81% in type of simple hyperplasia,1.27% and 52.3% in complex hyperplasia,and 3.49% and 36.81% in atypical hyperplasia tissues （P 0.05 or P 0.01）.There was a negative correlation between overexpression of NF-κB p65 and the expression of ERα in endometrioid adenocarcinoma（r = -0.491,P = 0.028）.Conclusion：The ectopic expressions of NF-κB p65 and ERα may play an important role in endometrioid carcinogenesis.
出处
《天津医药》
CAS
北大核心
2010年第5期369-371,共3页
Tianjin Medical Journal
