摘要
目的通过文献检索,总结目前中药有效成分抗子宫内膜癌的种类、研究方法及存在的不足,为研究中药抗子宫内膜癌新药奠定基础。方法通过以"中药""子宫内膜癌""有效成分"等为关键词检索知网数据库、万方数据库,及通过PUBMED检索英文摘要,从中选择近10年来,中药有效成分治疗子宫内膜癌的文献进行分析。结果中药有效成分对子宫内膜癌作用机制大致为影响雌激素受体拮抗雌激素作用,引起癌细胞DNA损伤,阻滞癌细胞周期,抑制癌细胞增殖,促进癌细胞凋亡,影响子宫内膜癌侵袭力,抑制子宫内膜癌新生血管生成及逆转耐药性等。结论中药有效成分通过影响子宫内膜癌性激素受体、细胞凋亡及抑制血管新生等细胞信号传导通路,抑制肿瘤生长,为中药抗子宫内膜癌的靶向治疗提供实验基础。
Objective To study the literature retrieval ,summarizes the present species ,effective components of traditional Chinese Medicine Anti endometrial cancer research methods and problems ,which lays the foundation for the research of new drugs of traditional Chinese Medicine Anti endometrial carcinoma .Methods By “Chinese medicine” ,“endometrial can-cer” ,“active ingredients”as keywords retrieval HowNet database ,Wanfang database ,and through the PUBMED search Eng-lish abstract ,choose from the past 10 years ,analysis of effective ingredients of Chinese medicine treatment of uterine en-dometrial carcinoma literature .Results From the effects of estrogen receptor antagonist action of estrogen induced cancer cells ,DNA damage ,cell cycle arrest cancer ,inhibit cancer cell proliferation ,promote apoptosis effects of cancer ,endometrial cancer invasiveness ,inhibition of angiogenesis in endometrial carcinoma generation and reversal of drug resistance and other point of view ,the progress of experimental summary of effective components of Chinese herbs on endometrial cancer mecha-nism ,and analyzes the deficiency in its research .Conclusion The effective components of traditional Chinese medicine through the influence of endometrial cancer hormone receptor ,apoptosis and inhibiting angiogenesis in cell signal transduc-tion pathways ,inhibiting the growth of tumor;for traditional Chinese Medicine Anti endometrial cancer target to provide the experimental basis to the treatment .
出处
《吉林中医药》
2015年第9期969-972,共4页
Jilin Journal of Chinese Medicine
基金
上海市卫计委科研基金课题(20134118)
上海市卫生三年行动计划海派基地建设项目(ZYSNXD-CC-HPGCJD-008)
关键词
子宫内膜癌
雌激素
癌细胞
endometrial cancer
estrogen
cancer cells
