摘要
目的:探讨胸腺肽α1对预防原发性肾病综合征频繁复发的疗效。方法:将原发性肾病综合征频繁复发的患儿60例随机分为治疗组和对照组,每组30例,均以泼尼松等综合治疗为主。治疗组在常规治疗的同时加用胸腺肽α1治疗(日达仙)1.6mg,皮下注射,每日1次,5d为1个疗程,必要时1周后再重复1个疗程,并在治疗前后和对照组分别抽血查CD3+,CD4+,CD8+,CD4+/CD8+T细胞亚群。结果:治疗后,治疗组CD4+、CD4+/CD8+增高,CD8+减低,差异有统计学意义(P<0.05);治疗组治疗后和对照组比较,CD4+、CD4+/CD8+增高,CD8+减低,差异有统计学意义(P<0.05)。治疗组复发次数明显小于对照组。结论:胸腺肽α1能有效地调节T细胞数量,提高细胞免疫功能,增强机体抗感染的水平,从而达到预防原发性肾病频繁复发的目的。
Objective: To explore the effect of thymosin alpha-1 on preventing primary nephrotic syndrome.Methods: Sixty frequently relapsing patients were randomly divided into intervention group(n = 30) and control group(n = 30).Both were given the comprehensive treatment (steroid).The patients of intervention group were also given thymosin alpha-1 (1.6 mg),injected hypodermically,5 days a term,another term was repeated if necessary.The levels of CD3+,CD4+,CD8+ and CD4+/CD8+ were tested before and after the intervention.Results: The levels of CD3+,CD4+ and CD4+/CD8+ increased and CD8+ decreased more significantly after the treatment(P < 0.05).The levels of CD4+ and CD4+/CD8+ increased more significantly,but CD8+ decreased more significantly in the intervention group than those in control group (P < 0.05).The relapse rate was significantly lower in the intervention group than that of the control group.Conclusion: Thymosin alpha-1 can regulate T cell effectively,increase cell immunity,enhance the immunity to infection and prevent frequent relapse of primary nephrotic syndrome.
出处
《天津医药》
CAS
北大核心
2010年第5期363-365,共3页
Tianjin Medical Journal
关键词
肾病综合征
化学预防
T淋巴细胞亚群
复发
胸腺肽Α1
儿童
nephrotic syndrome chemoprevention T-lymphocyte subsets recurrence thymic peptide α1 child
