摘要
目的:研究药物和运动干预对社区绝经后女性骨质疏松高危人群的临床症状改善的有效性。方法:从社区中挑选绝经两年以上,年龄60～65岁的女性300人作为研究对象。根据随机化原则,将其分成3组:A组:钙+活性VitD(骨化三醇)组;B组:强化运动组;C组:空白对照组。分别给予相应干预措施,记录在干预前及干预一年后受试者骨痛、腰背疼痛等症状改善的人数;通过站立试验测试所有受试者下肢肌力变化的程度;采用视觉类比量法(VAS)比较干预前后各组骨质疏松临床症状的改善程度。结果:社区干预组中A组骨痛、腰背疼痛等症状有明显改善的人数高于B组(P<0.05),C组症状改善人数最少;站立试验中B组干预效果明显,所用时间少于A组,对照组无明显提高。结论:通过给绝经后女性补充钙和活性VitD(骨化三醇),其骨质疏松的临床症状有较为明显的改善;户外运动有助于提高骨质疏松高危人群的四肢肌力。因此,合理的补充钙和活性VitD并且结合适量户外运动,均可以有效的改善骨质疏松的临床症状,提高生活质量。
Objective：To investigate the effect of drug and exercise intervention on the clinical symptoms of osteoporosis in postmenopansal women who are at high risk of osteoporosis.Methods：Selected from the community for more than two years of menopause,300 women aged 60-65 years old served as research subjects. According to the principle of randomization, the subjects were divided into 3 groups. The groups were given the appropriate intervemions,respectively： A： Calcium and active VitD （calcitriol） group; B： exercise group; C： blank control group. Clinical symptoms such as bone pain,low back pain and others in the subjects were recorded before and one year after the intervention.;the change of muscle strength in the lower limb was evaluated by floor standing test; the improvement of clinical symptoms was estimated by using visual analogue （VAS） .Results： The number of subjects with improved symptoms in group A was significantly more than group B. It had statistic difference.（P〈0.05）;The subjects in group C showed the less improvement in clinical symptoms. The results of the floor standing test showed that the muscle strength of group B was better than group A and the blank control. The time group B used was less than the others. Conclusion：The clinical symptoms of osteoporosis in postmenopausal women were improved obviously by administrating additional Calcium and active VitD, and the muscle strength in the lower limbs was enhanced by outdoor sports. Therefore, Reasonable complement of calcium and active VitD combining with moderate outdoor sports may improve the clinical symptoms of osteoporosis and the quality of their life
出处
《中国医药导刊》
2010年第5期907-909,共3页
Chinese Journal of Medicinal Guide
基金
"十一五"国家科技支撑计划项目(2006BAI02B03)
关键词
绝经后骨质疏松症
药物干预
运动干预
Postmenopansal osteoporosis
Drug intervention
Exercise intervention
