摘要
目的分析基层医院与社区获得性肺炎患者病原菌分布及耐药性,为临床抗感染治疗提供依据。方法对2005年6月-2009年6月门诊及住院部送检痰标本进行细菌分离培养与鉴定,并对医院获得性肺炎与社区肺部感染患者病原菌分布及耐药性进行对比分析。结果从社区获得性肺部感染患者标本分离培养出病原菌117株,分离的主要病原菌依次为肺炎链球菌(24.8%)、肺炎克雷伯菌(16.2%)、铜绿假单胞菌及金黄色葡萄球菌(均为12.0%);医院获得性肺炎患者标本分离培养出病原菌208株,分离的主要病原菌依次为铜绿假单胞菌(24.0%)、肺炎克雷伯菌(18.8%)、大肠埃希菌(11.1%),社区与医院获得性肺炎患者病原菌分布差异有统计学意义;革兰阳性菌对常规抗菌药物耐药率高。结论临床在抗感染治疗中,应结合该地区及医院病原菌变化分布特点,实行优化性的经验性的治疗,结合实验室检测及药敏试验,合理使用抗菌药物。
OBJECTIVE To analyze the distribution and drug resistance of pathogens isolated from patients in Hospital-acquired pneumonia （HAP） and community-acquired pneumonia, （CAP）so as to provide evidence for clinical anti-infective treatment. METHODS Bacterial strains from patients in clinical departments from June 2006 to June 2009 were isolated and identified, pathogenic distribution and antimicrobial resistance between HAP. and CAP were compared and analyzed. RESULTS 117 strains were isolated from patients in CAP. Among them, the main isolated pathogens were Streptococcus pneurnoniae （24.8 % ） K lebsiella pneurnoniae （16.2% ）, Pseudomonas aeruginosa （12.0%）, Staphylococcus aureus （12.0%） strains were isolated from patients in CAP. Among the 208 strains pathogens, the most common pathogens in HAP were Bracteata bacteria P. aeruginosa （24.0 %）, K. pneurnoniae （18.8 %）, Escherichia coll （11.1%） ; There was statistical difference between HAP and CAP. The Gram-negative bacteria had high drug resistance rate to genera1 antibiotics. CONCLUSIONS In the clinical antiinfective therapy, optimization of empirical treatment should be implemented, combining with changes in the region and the distribution of pathogenic bacteria in hospital characteristics. Antibiotics should be used rationally, combining with laboratory testing and antibiotic susceptibility, experiments.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2010年第12期1797-1798,共2页
Chinese Journal of Nosocomiology
关键词
医院获得性肺炎
社区获得性肺炎
病原菌
抗菌药物
Hospital acquired pneumonia
Community acquired pneumonia
Pathogens
Antibiotics
