摘要
目的:研究辛伐他汀作为激活物对骨生成的促进作用。方法:通过制备大鼠胫骨骨缺损模型填入Bio-oss骨粉,同时给予口服辛伐他汀(实验组),并设立空白组、对照组(骨缺损单纯填入Bio-oss骨粉),于术后4、8、12周分别处死大鼠,进行定性、定量分析,观测骨增量变化。结果:空白组无法形成正常骨愈合;实验组在骨量形成和新骨改建速度方面明显优于对照组。结论:辛伐他汀有促进新骨生成作用。
Objective：To study stimulation of bone formation by statins（simvastatin）as a activation.Method：72 SD rats（3mm defect of left tibia）were random treated with three groups：1.untreated group;2.comparison group：Bio-oss alone be filled in defect of tibia;3.experiment group：compounding simvastatin be taken orally.The rats were sacrificed in 4、8 and 12 weeks and the bone formation was observed.Result：The difference was obvious in 8 and 12 weeks.Compared group 2 and 3,the bone formation of group 3 was better in quality and velocity.Conclusion：Simvastatin as a activation can improve bone formation in defect of rats tibia.
出处
《临床口腔医学杂志》
2010年第4期214-217,共4页
Journal of Clinical Stomatology
基金
广东省自然科学基金项目(32569)
关键词
辛伐他汀
骨缺损
成骨作用
simvastatin
defect of tibia
bone formation
