摘要
目的:观察C反应蛋白(CRP)和D-二聚体(D-D)在骨折不愈合患者诊治中的意义,以探讨炎症和血栓形成与骨折不愈合的关系。方法:分别检测31例骨折患者在骨折治疗前、延迟愈合期以及不愈合期血浆CRP、D-D、纤维蛋白原(FIB)以及血小板聚集率(PAgT)水平,并计算各指标间的相关性和阳性百分率。结果:骨折患者从治疗前进展到延迟愈合期以及不愈合期,血浆CRP、D-D、FIB和PAgT均呈显著升高趋势(P<0.001或P<0.01);并且CRP、D-D、FIB和PAgT在患者中的阳性率也呈升高趋势(P<0.001或P<0.01),各阶段CRP的阳性率最高,其次为D-D。CRP与D-D、FIB以及PAgT呈显著正相关(P<0.001或P<0.01)。结论:炎症和血栓形成与骨折不愈合均有密切的关系,血栓形成可能是导致骨折不愈合的又一个重要因素。
Objective：To observe the clinical significance of C reaction protein and d-dimer in patients with non-union of fracture,so as to evaluate the association of inflammation and thrombosis with non-union of fracture.Methods：Samples were gathered from 31 patients in three stages of pre-treatment,delayed union and non-union of fracture,respectively.The plasma C reaction protein,d-dimer,fibrinogen and ratio of platelet aggregation were determinted.The correlation among the four indicators one another was analyzed,and the positive rates of all indicators were calculated,too.Results：With the progress of disease stages from pro-treatment to delayed union and non-union of fracture,the levels of plasma C reaction protein,d-dimer,fibrinogen and the ratio of platelet aggregation kept a marked increasing（P〈0.001 or P〈0.01）.And the positive rates of the four indicators had the same remarkable changes as their levels（P〈0.001 or P〈0.01）.In all the three stages of fracture,there were highest positive rates of C reaction protein,the second was d-dimer.There was a significant positive correlation between C reaction and one of d-dimer,fibrinogen and the ratio of platelet aggregation（P〈0.001 or P〈0.01）.Conclusion：There is a close relationship between non-union of fracture and inflammation as well as thrombosis.Thrombosis may be one of the immportant causes for non-union fracture.
出处
《中国卫生检验杂志》
CAS
2010年第5期1133-1134,1152,共3页
Chinese Journal of Health Laboratory Technology
关键词
骨折不愈合
炎症
血栓形成
Non-union
Fracture
Imflammation
Thrombosis
