摘要
RGC-32（response gene to complement-32）为重要的补体应答基因，同时也参与了其他生物学功能。近来研究发现许多因子如膜攻击复合物、皮质激素、生长因子、黄体生成素及转化生长因子β等均可诱导RGC-32表达，并在细胞增殖分化、炎症反应、肿瘤转移等过程中起关键作用，从而参与人类许多疾病的发生发展过程。但RGC-32确切的细胞生物学功能、亚细胞定位、基因调控机制等尚有待阐明。
Response gene to eomplement-32（RGC-32）as one of important response genes to complement, involves in many biological funetions. Recent studies found that many factors could induce the expression of RGC-32 such as membrane attack complex, cortical hormones, growth factors, luteinizing hormone and trarsforming growth factor-β and so on. Tne expression products of RGC-32 play a key role in cell proliferation, differentiation, inflammation, tumor metastasis and other processes, thus to participate in the occurrence of many diseases＇ development processes. However, it has not be clarified in its exact cell biological function, subeellular localization, gene regulation mechanism. Tiffs article will make a brief review on gene structure, funetious and roles in cell biology as well as the relationship between human diseases for RGC-32.
出处
《国际儿科学杂志》
2010年第3期320-322,共3页
International Journal of Pediatrics
基金
国家自然科学基金资助项目（30871177）
关键词
RGC-32
膜攻击复合物
细胞增殖分化
转化生长因子Β
肾小管上皮.间质转化
RGC-32
Membrane attack complex
Proliferation and differentiation
Transforming growth faetor-β
Renal. tubular epithelial-mesenehymal transition
