摘要
目的探讨RGC32(response gene to complement 32)在子宫颈鳞状细胞癌及鳞状上皮内病变组织中的表达以及临床意义。方法采用免疫组化法分别检测正常宫颈、低度鳞状上皮内病变(LSIL)、高度鳞状上皮内病变(HSIL)、鳞状细胞癌组织(SCC)中RGC32蛋白的表达情况,并且分析RGC32表达与宫颈鳞状细胞癌临床特征的关系。结果宫颈鳞状细胞癌及高度鳞状上皮内病变中RGC32的阳性率显著高于低度鳞状上皮内病变及正常宫颈(P<0.05)。RGC32蛋白在有淋巴结转移组阳性率显著高于无淋巴结转移组(P=0.014)。结论 RGC32在癌前病变及SCC中的阳性率显著高于非癌前病变,同时在发生淋巴结转移组阳性率显著高于无淋巴结转移组,提示RGC32可能参与了宫颈癌的发生、发展过程。
Objective To explore the expression and clinical significance of RGC 32 in SCC and squa- mous intraepithelial lesion. Methods The expression of RGC 32 was detected by the immunohistochemistry meth- od in normal cervical, LSIL, HSIL and SCC. Then the relationship between expression RGC 32 and the clinical characteristics in terms of occurrence and metastasis of cervical cancer was analyzed. Results The expression of RGC32 in SCC and the HSIL were significantly higher than that in the LSIL and normal cervix （P 〈 0.05 ）. The ex- pression of RGC32 in carcinoma with lymph node metastasis were significantly higher than that without lymph node metastasis. Conclusion RGC32 may play an important role in the occmTence and metastasis of cervical cancer.
作者
田杰
周东华
平静
秦艳
刘小燕
陈莹
范菊花
TIAN Jie;ZHOU Donghua;PING Jing;QIN Yan;LIU Xiaoyan;CHEN Ying;FAN Juhua(Department of Pathology,Maternal and Children＇S Hospital of Foshan,Foshan 528000,China Corresponding author ： ZHOU Donghua E-mail ： 420351094@qq.com)
出处
《实用医学杂志》
CAS
北大核心
2018年第16期2777-2779,共3页
The Journal of Practical Medicine
基金
广东省佛山市卫生和计划生育局医学科研项目(编号:20160056)
