摘要
应用ＡＢＣ免疫组化法对９３例膀胱移行细胞癌组织中的原癌基因ｃ－ｅｒｂＢ－２和抑癌基因Ｐ５３的表达及共同表达的意义进行了研究。结果显示：ｃ－ｅｒｂＢ－２和Ｐ５３的阳性表达率分别为２６％和４８％，二者共同表达率为２１．５％，共同表达与肿瘤的病理分级（Ｐ＜０．０５），临床分期（Ｐ＜０．０１），复发（Ｐ＜０．０５）关系极为密切。提示ｃ－ｅｒｂＢ－２和Ｐ５３与膀胱移行细胞癌的发生、发展、尤其与肿瘤的侵袭性密切相关，并且二者可能有协调作用。同时检测两者的表达情况，可为临床判断膀胱移行细胞癌预后提供可靠的依据。
The ABC immunohistochemical method was used in study the expression of c-erbB-2 and protein P 53 in transitional cell bladder carcinoma from 93 patients. It showed that the positive expressive rates of c-erbB and P 53 protein were 26% and 48% respectively, and the common expressive rate of the two was 21.5%, and the common expression was closely ralated to the pathological grading (P<0.05), to the clinical stages (P<0.01), and to the recurrence (P<0.05) of the carcinoma. It was suggested that c-erbB-2 and protein P 53 had close correlation to the formation and progress of the carcinoma, especially the invasive, moreover, the two may have coordinate function. The assay of c-erbB-2 and P 53 may help to the clinical judgement of the prognose of transitional cell bladder carcinoma.
出处
《右江民族医学院学报》
1999年第1期14-16,共3页
Journal of Youjiang Medical University for Nationalities
