摘要
目的：研究抑癌基因P53在舌癌及癌前病变中的表达。方法：采用免疫组化技术对正常舌粘膜，单纯性上皮增生，轻、中、重度不典型增生，以及舌鳞疾进行了抑癌基因P53表达相关分析。结果：正常舌粘膜基底细胞中偶见阳性细胞（2／5）；单纯性上皮增生中基底层细胞阳性率增加（3／5）；轻、中、重度不典型增生P53阳性细胞逐渐增多（阳性率分别为6O％，80％，80％）；舌鳞癌阳性率为80％（20／25）。结论：P53过度表达与舌癌的发生关系密切。
Objective: To study tumor-suppressor gene P53 overexpression in human lingual precancerous and cancerous lesions. Met heds: Tumor- suppressor gene P53 overexpression was analysed with the development of lingual mucosal carcinogenesis by immunohistochemistry. Results:Only a few positive basal cells were found in normal lingual mucosa (2 of 5 cases);positive cells incereased in hyperplasia,but confined to basal layer (3 of 5 cases);and from low to high degree of dysplasia,P53 positive cells incresed significantly, not confined to basal layer (positive rate was 6O%, 8O%, 8O%,respectively); 20 of 25 cases (80% ) of lingual Squamous cell carcinry mas were positively stained. Conclusion:The results indicated that P53 overexpression is closcly related with lin-gual mucosal carrinogenesis.
出处
《白求恩医科大学学报》
CSCD
1998年第2期152-153,共2页
Journal of Norman Bethune University of Medical Science
基金
吉林省卫生厅青年科学基金!94081
