摘要
目的研究ｎｍ２３－Ｈ１，ＰＣＮＡ在肺癌中的表达与肺癌转移的关系。方法应用免疫组化ＳＰ法检测４７例肺癌中ｎｍ２３－Ｈ１，ＰＣＮＡ的表达。结果原发性肺癌中ｎｍ２３－Ｈ１，ＰＣＮＡ的阳性率分别为５１．０６％和６５．９６％。其中ｎｍ２３－Ｈ１在鳞癌中的阳性率４３．３３％（１３／３０），腺癌６４．７０％（１１／１７）。在鳞癌中无肺门及纵膈淋巴结转移阳性率６２．５％（１０／１６），有转移组阳性率２１．４２％（３／１４），差异有显著性（Ｐ＜０．００１），ｎｍ２３－Ｈ１表达与鳞癌的淋巴结转移呈负相关。在ＰＣＮＡ表达中有淋巴结转移阳性率８２．６％（１９／２３），无转移组５４．１６％（１３／２４）（Ｐ＜０．００１），同时低分化癌的阳性率８８．８８％（８／９）明显高于高分化癌４３．７５％（７／１６），（Ｐ＜０．００１）。结论ｎｍ２３－Ｈ１，ＰＣＮＡ的表达对肺癌予后评估有一定意义。
Purpose To study the expression of nm23-H 1,PCNA in human lung carcinoma.Methods The expression of nm23-H 1,PCNA, in 47 cases human lung carcinoma was studied with SP immunohistochemical technique.Results In human lung carcinoma,the positive expressions of nm23-H 1,PCNA,were 51.06% and 65.96% .The nm23-H 1 in squamous cell carcinoma was 43.33% ,adenocarcinoma 64.7% .The positive in squamous cell carcinoma without metastasis of hilar or mediastinal lymph node was 62.5% (10/16) ,metustusis of lymph node was 21.4% (3/14),(p< 0.001 ).The nm23-H 1 expression level was inversely correlated with lymph node metastasis in squamous cell carcinoma.The positive expression of PCNA in lymph node metastasis was 82.6% (19/23)without metastasis was 54.16% (P< 0.001 ),It was 88.88% (8/9) in the low differentiation carcinoma.It was 43.75% (7/16) hight differentiation carcinoma (P< 0.001 ).Conclusions The expression of nm23-H 1,PCNA may be useful to evaluate the prognosis of lung carcinoma.
出处
《中国肿瘤临床与康复》
1999年第1期21-22,共2页
Chinese Journal of Clinical Oncology and Rehabilitation
