摘要
目的:探讨基质金属蛋白酶-7(MMP-7)及其组织抑制剂-1(TIMP-1)与胃癌发生发展的关系。方法:采用免疫组化技术检测46例胃癌组织和相应癌旁组织中MMP-7和TIMP-1的表达,结合病人临床病理资料进行综合分析。结果:胃癌组织中MMP-7阳性表达率(60.87%)显著高于相应癌旁组织,差异有统计学意义(P<0.05);其表达与淋巴结转移(P<0.05)相关。胃癌组织中TIMP-1的阳性表达率(93.48%)明显高于相应癌旁组织(63.04%),差异有统计学意义(P<0.05);其表达与淋巴结转移相关(P<0.05)。结论:MMP-7与胃癌的侵袭转移有关,TIMP-1有可能成为评价胃癌恶性生物学行为的指标。
Objective：To study the relationship between MMP-7 and TIMP-1 expression and gastric carcinoma.Methods：To detect the expression of MMP-7 and TIMP-1 in 46 gastric carcinoma tissues and para-gastric carcinoma tissues by immunohistochemistry and analyze the result with consolidation of clinical pathological materials.Results：The positive rate of MMP-7 in gastric carcinoma（60.87%） was higher than corresponding para-gastric carcinoma.There was statistical significance（P0.05）,having correlation with lymphaden metabasis（P 0.05）.The positive rate of TIMP-1 in gastric carcinoma（93.48%） was higher than corresponding para-gastric carcinoma（63.04%）.There was statistical significance（P0.05）,having correlation with lymphaden metabasis（P 0.05）.Conclusion：MMP-7 is concerned with the invasion and metabasis of gastric carcinoma,TIMP-1 could be the index to evaluate the biological behaviour of gastric carcinoma.
出处
《现代生物医学进展》
CAS
2010年第7期1315-1318,共4页
Progress in Modern Biomedicine
