摘要
目的:研究大肠癌中基质金属蛋白酶-7(MMP-7)和血管内皮生长因子(VEGF)的表达情况,探讨其表达的临床意义及关系,以指导临床工作。方法:选取我院诊治的96例大肠癌组织作为观察组,同期正常结肠黏膜组织80例作为对照组,应用免疫组织化学方法检测两组中MMP-7和VEGF的表达,分析MMP-7和VEGF表达的关系及不同临床特征的表达差异。结果:观察组MMP-7和VEGF表达阳性率明显高于对照组(P均<0.05),并且与肿瘤的分化程度、浸润深度、淋巴结转移及Dukes分期密切相关(P均<0.05)。观察组MMP-7和VEGF的表达呈正相关(r=0.42,P=0.019 7)。结论:MMP-7和VEGF在大肠癌的发生、发展中具有促进作用,二者可能具有协同正向作用,术后联合检测MMP-7和VEGF的表达可能有助于患者预后的判断。
Objective： To detect the expressions of MMP-7 and VEGF protein in colorectal carcino- ma, and investigate their clinical significance and relationship in neoplasm. Methods： The study included 96 cases of colorectal carcinoma as experimental group and 80 cases of normal colorectal mucosa tissues as control group. The expressions of MMP-7 and VEGF in different pathological characters were detected by using IHC, and their relationship in neoplasm was analyzed. Results The positive expressions of MMP-7 and VEGF were significantly higher in the colorectal carinoma than in normal tissues（P〈0.05）. The expression was correlated with differentiation, invasive depth, lymph node metastasis and Dukes stage. Positive correlation between MMP-7 and VEGF were found in colorectal carcinoma. Conclusions： The protein of MMP-9 and VEGF may promote the development of colorectal carcinoma. The combined examination may be helpful to predict the prognosis in colorectal carcinoma.
出处
《海南医学院学报》
CAS
2011年第11期1465-1467,共3页
Journal of Hainan Medical University
基金
海南医学院科研基金资助学报项目(0020110403)~~
