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乳腺癌耐药蛋白/ATP结合转运蛋白G超家族成员单核苷酸多态性研究进展

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摘要 乳腺癌耐药蛋白(breast cancer resistance protein,BCRP)是ATP结合转运蛋白(ATP-binding cassette,ABC)超家族成员之一,ABC在人肿瘤细胞和正常组织均有表达,参与多种物质的吸收、分布和排泄,并在机体组织防御过程中发挥重要作用。编码BCRP的ABCG2基因单核苷酸多态性(SNP)在BCRP的表达和功能、底物的体内过程、抗癌药物的化疗效果等方面均有重要意义。
机构地区 中江县人民医院
出处 《华西医学》 CAS 2010年第2期434-436,共3页 West China Medical Journal
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参考文献10

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