摘要
目的:了解ICU病房主要革兰阴性菌对常用抗菌药物的敏感性,以便合理使用抗菌药物。方法:收集我院ICU病房2004～2008年分离出的病原菌菌株,采用纸片扩散法进行药物敏感性试验。结果:2004～2007年革兰阴性菌的菌株数有上升趋势,在2008年全院控制药品比例的前提下,2008年革兰阴性菌的总菌数有所下降。分离数占前3位的细菌分别是大肠埃希菌、铜绿假单胞菌和鲍曼不动杆菌,除碳青霉烯类、酶抑制剂类、第4代头孢菌素类保持不同程度敏感性外,其余大多数抗菌药物均已耐药。结论:做好细菌敏感性监测,根据药动学/药效学(PK/PD)理论优化抗菌药物对于临床治疗有重要意义。
OBJECTIVE： To investigate sensitivity of main gram-negative bacteria to normal antibiotics in ICU ward in order to use antibiotics rationally. METHODS： Isolated strains in ICU ward from 2004 to 2008 were collected for drug sensitivity test using disc diffusion method. RESULTS： Amount of gram-negative bacterial strain increased during the first four years while decreased in 2008 under the premise of control of drug proportion. The top three among those strains were Escherichia coli, Pseudomonas aeruginosa and Acinetobacter baumannii. Most of antibiotics were well tolerated except of carbapenems, enzyme inhibitors and the fourth-generation cephalosporins remaining different degrees of sensitivity. CONCLUSION：It is significant for clinical treatment to monitor the sensitivity of bacteria and optimize antibiotics according to pharmacokinetics and pharmacodynamics（PK/PD）.
出处
《中国药房》
CAS
CSCD
北大核心
2010年第18期1674-1676,共3页
China Pharmacy
