摘要
目的:了解武汉地区各型病毒性肝炎患者中庚型肝炎病毒(HGV)感染的情况。方法:用酶联免疫吸附试验(ELISA)及逆转录聚合酶链反应(RT-PCR)方法测定各型病毒性肝炎患者的抗HGV和HGV RNA,并对庚肝病毒感染者进行临床分析。结果:351例各型病毒性肝炎患者中抗HGV阳性者56例,占15.05％;此56例中HGV RNA阳性者21例,占37.50％。各型病毒性肝炎患者中抗HGV阳性率及庚肝抗体阳性者中HGV RNA阳性率分别为:甲肝14.29％(5/35)及20.00％(1/5);乙肝17.29％(37/214)及35.14％(13/37);丙肝14.52％(9/62)及55.56％(5/9);戊肝4.00％(1/25),0.00％(0/1);非甲～戊肝26.67％(4/15),50.00％(2/4)。56例抗HGV阳性者中43例有输血、使用血制品或静脉药癌史,占76.79％。HGV感染在肝炎各临床类型分布为急性、慢性和重型肝炎患者无明显差异,且无性别和年龄分布的差异。HBV重叠感染HGV患者的SALT及TBil水平明显高于单纯HBV感染者(P<0.05),而HGV和其它肝炎病毒((HAV、HCV、HEV)重叠感染患者与单纯其它肝炎病毒感染者的SALT及TBiL水平无明显差异(P>0.05)。结论:武汉地区各型病毒性肝炎患者均可存在HGV感染。HGV可单独感染或与其它病毒混合感染。血液传播是HGV感染的主要途径。乙型肝炎患者合并庚肝病毒重叠感染可加重病情,而甲、丙。
Aim: To evaluate the prevalence and significance of HGV infection in various forms of viral hepatitis. Methods: HGV antibody and HGV RNA in serum were detected respectively by ELISA and RT-PCR. Results; HGV-Ab was positive in 56 of 351 patients with viral hepatitis (15. 05%) and among them 21 were positive with HGV-RNA (37. 50%). HGV-Aband HGV RNA positive rates were 14. 29% (5/35) and 20. 00% (1/5) respectively in Hepatitis A, and 17.29% (37/214) and 35.14% (13/37) in Hepatitis B. 14.52% (9/62) and 55. 56% (5/9) in Hepatitis C. 4.00% (1/25) and 0. 00% (0/1) in Hepatiits E. 26. 56% (4/15) and 50. 00% (2/4) in Hepatitis non A-E. 43 patients infected with HGV (76. 76%) have history of recepting blood products or abusing intravenous drugs. HGV infecting rate showed no difference concerning clinical type of hepatitis as well as sex and age. The patients coinfected with HBV and HGV developed more serious liver damage than that infected with HBV alone (P<0. 05). Conclusion: In Wuhan area, patients could be coinfected by HGV and other various forms of hepatitis virus. HGV could exist alone and coexists with other hepatitis virus as well. Bloodtransmission is the most important routs of HGV infection. HGV could make hepatitis B worse.
出处
《中西医结合肝病杂志》
CAS
1999年第1期2-4,共3页
Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases
基金
363课题资助(102-07-02-07)
关键词
病毒性肝炎
庚型肝炎
ELISA
聚合酶链反应
Viral Hepatitis Hepatitis G Virus (HGV) Polymerase Chain Reaction (PCR) Enzyme-linked Immunosorbent Assay (ELISA)
