摘要
脂联素是由脂肪组织分泌的一种细胞因子,与心血管疾病密切相关。脂联素通过抗炎和抗氧化抑制动脉粥样硬化发生。脂联素可促进血管生成,并具有保护心肌免受缺血再灌注损伤和减轻高压力负荷导致的心肌肥厚的功能。脂联素主要通过激活腺苷酸活化的蛋白激酶、环磷酸腺苷-蛋白激酶A等信号通路而发挥对心血管的保护作用。该文主要针对脂联素在心血管系统中的作用及其分子机制的研究进展作一综述。
Adiponectin is secreted by adipose tissue and is highly associated with cardiovascular diseases. Adiponectin inhibits artherosclerosis through anti-inflammatory and anti-oxidative mechanisms. Adiponetin promotes angiogenesis. Adiponectin protects hearts from ischemic reperfusion injury or myocardial hypertrophy induced by high pressure. The cardiovascular protection effects of adiponectin are mainly attributed to the activation of signaling pathways,including AMP-activated protein kinase pathway and cAMP-protein kinase A pathway. This article reviews the current knowledge about the role of adiponectin in cardiovascular systems and its molecular mechanisms.
出处
《生命科学》
CSCD
北大核心
2010年第4期313-316,共4页
Chinese Bulletin of Life Sciences
基金
国家自然科学基金项目(30971187)
浙江省自然科学基金项目(Y2091198)
关键词
脂联素
动脉粥样硬化
血管生成
再灌注损伤
心肌肥厚
adiponectin
artherosclerosis
angiogenesis
ischemic reperfusion injury
myocardial hypertrophy
