摘要
目的评价FOLFOX4方案治疗晚期大肠癌的疗效与安全性。方法按FOLFOX4方案给药,奥沙利铂85mg/m2,静脉滴注2h,第1d;CF200mg/m2,静脉滴注2h,第1,2d;5-FU400mg/m2,于CF滴完后静脉注射10min,第1,2d;5-FU600mg/m2,持续泵入22h,第1,2d;每2~3周重复。结果入组观察48例,可评价疗效者48例,其中CR5例（10.4%）,PR14例（29.2%）,CR＋PR共19例,近期客观有效率39.6%;SD 20例（41.7%）,PD 9例（18.8%）。中位TTP 9.3个月,中位OS 22.4个月。不良反应主要为白细胞减少,消化道不良反应较轻,较明显的毒副反应为周围神经毒性,无化疗相关死亡。结论FOLFOX4方案治疗晚期大肠癌癌疗效较高,不良反应轻而且安全。
Objective To evaluate the efficiency and toxicity of the chemotherapy regimen FOLFOX4 for the patient with advanced colorectal cancer.Methods Oxaliplatin 85 mg/m2 i.v.over 2 hours,day 1,Leucovorin 400mg/m2 i.v.over 2 hours,days 1 and 2,5-FU 400mg/m2 i.v.bolus,then 600mg/m2 i.v.over 22 hours continuous infusion,days 1 and 2,Repeat every 2 or 3 weeks.Results Totally 48 patients with advanced colorectal cancer entered the study.Among them 5 patients reached complete response（CR）,14 partial response（PR）.The overall response rate（CR＋ PR） was 39.6%.Conclusion FOLFOX4 regimen show good efficacy with mild toxicity in treatment of advanced colorectal cancer.
出处
《医药论坛杂志》
2010年第7期9-10,共2页
Journal of Medical Forum
关键词
大肠癌
化疗
奥沙利铂
亚叶酸钙
5-氟尿嘧啶
Colorectal cancer
Chemotherapy
Oxaliplatin
Leucovorin
5-fluorouracil
