摘要
目的通过回顾分析三阴性乳腺癌病例资料,探讨三阴性乳腺癌的临床及预后情况。方法收集ER、PR和HER-2均阴性的136例乳腺癌患者的临床资料,行Cox多元回归分析。结果136例患者确诊时,中位年龄47岁;有乳腺癌家族史者9例(6.6%),浸润性导管癌124例(91.2%),T3分期以上23例(16.9%),区域淋巴结阳性者60例(44.1%)。中位随访时间59个月(31～86个月),复发及转移患者41例(30.1%),死亡24例;5年无病生存率(DFS)和总生存率(OS)分别为69.6%和84.1%;术后复发转移,以肺内转移的发生率最高,其次是肝脏。术后中位复发时间为26个月(5～62个月),复发后3年生存率为35.2%。单因素分析显示,肿瘤大小、淋巴结转移数目、病理分期、辅助化疗周期数等与三阴性乳腺癌的预后有关。Cox多元回归分析显示,淋巴结转移数目是预测三阴性乳腺癌预后的独立因素。结论三阴性乳腺癌具有发病年龄较轻、确诊时淋巴结转移率较高、临床分期较晚、术后早期复发率高、复发后生存时间短等特征,淋巴结转移数目为三阴性乳腺癌预后的独立指标。
Objective Triple-negative breast cancer is defined by a lack of expression of estrogen receptors,progesterone receptors,and human epidermal growth factor receptor-2（HER-2）,which is considered to be a disease with aggressive behaviors and poor prognosis.The aim of the study was to analyze the clinicalpathologic characteristics,survival and prognostic factors of triple-negative breast cancer.Methods Clinicalpathologic data of 136 patients with triple-negative breast cancer were collected from Jan.1999,to Dec.2004,and the clinicalpathologic characteristics,recurrence and survival of the patients were analyzed.Results The median age of 136 patients with triple-negative breast cancer was 47 years.Of the 136 patients,9 had breast cancer family history,and 91.2% were invasive ductal carcinomas.At diagnosis,16.9% of the tumors were over stage T3,and 44.1% were lymph node positive.By Dec.2007,the median time of follow was 59 months（31-86 months）,41 had local recurrence and metastasis,and 24 died.The 5-year disease-free survival（DFS）and overall survival（OS）were 69.6% and 84.1%,respectively.97.6% of recurrence occurred in five years after treatment.The incidence of lung metastasis and liver metastasis was higher.The median survival time after recurrence was 26 months（5-62 months）,and the rate of OS in 3 years was only 35.2%.Simple factor analysis showed that tumor size,lymph node status,pathologic stage,and the number of chemotherapy cycle were found to be correlated with OS.Multivariate Cox regression showed that lymph node status were the only factor influencing the prognosis of triple-negative.Conclusion Triple-negative breast cancer was characteristic of younger,more lymph node metastasis at diagnosis,advanced pathologic stage,higher rate of early recurrence and shorter survival time after recurrence,the lymph node status may be one of independent prognosis factors of triple-negative breast cancer.
出处
《临床肿瘤学杂志》
CAS
2010年第4期339-342,共4页
Chinese Clinical Oncology
关键词
三阴性乳腺癌
临床特征
预后
Triple-negative breast cancer
Clinical characteristics
Prognosis
