摘要
目的:检测环氧化酶-2(COX-2)在寻常型银屑病炎性皮损中的表达,并分析与血管新生的关系。方法:用免疫组织化学SP法检测30例寻常型银屑病炎性皮损组织和10例正常皮肤组织中COX-2、血管内皮生长因子(VEGF)的表达,并进行相关性分析。结果:寻常型银屑病炎性皮损中COX-2表达水平明显高于对照组(P<0.05),COX-2与VEGF表达呈正相关(r=0.866,P<0.05)。结论:寻常型银屑病炎性皮损中存在COX-2高表达,后者可能通过上调VEGF的表达促进银屑病皮损处血管新生,在寻常型银屑病进展期起重要作用。
Objective： To measure the expression of COX- 2 （ cyciooxygenase- 2） in patients with active psoriasis vadgaris and to correlate the expression with angiogenesis. Methods： The expression of COX - 2 and vascular endothelial growth factor （VEGF- A） was detected by immunohistochemistry in lesions of 30 patients with active psoriasis and 10 normal skin samples. The correlation between the expression of COX- 2 and VEGF- A was analyzed. Results： The expression of COX - 2 in psoriatic tissue was significantly higher than that in normal samples. The expression of COX - 2 was positively correlated to the expression of VEGF （ r = 0. 866, P 〈 0.05 ）. Conclusion： COX - 2 is over - expressed in active psoriasis, which up - regulates the expression of VEGF to promote angiogensis. Therefore, COX - 2 may play an important role in the activity of the disease.
出处
《中国麻风皮肤病杂志》
2010年第4期249-251,共3页
China Journal of Leprosy and Skin Diseases
