摘要
目的探讨CXCL12及血管内皮生长因子(VEGF)在食管鳞癌组织中的表达及其意义。方法应用免疫组化SP法检测60例食管鳞癌组织及其对应的60例上端切缘组织(作为正常对照组织)中CXCL12及VEGF的表达水平。结果食管鳞癌组织中CXCL12、VEGF阳性表达率分别为58.33%、63.33%,均分别高于正常对照组织中CXCL12和VEGF的表达(0.00%、0.00%)(P<0.05)。CXCL12、VEGF的表达均与食管鳞癌的浸润深度、TNM分期及淋巴结转移有关(P<0.05),与患者的年龄、性别及食管鳞癌的肿瘤部位、肿瘤长度无统计学意义(P>0.05)。CXCL12、VEGF两者在食管鳞癌组织中的表达呈正相关(RS=0.479,P<0.05)。结论食管鳞癌组织中CXCL12、VEGF表达均显著增高,两者在食管鳞癌浸润和淋巴结转移中可能具有协同作用。
Objective To study the expression and significance of the CXCL12 and VEGF in esophageal cancer.Methods The expression of CXCL12 and VEGF protein in 60 specimens of esophageal cancer and 60 cases corresponding to the top of the cutting edge of the organization （as normal control） were assessed by immunohistochemistry.Results The positive expression rates of CXCL12 and VEGF protein in esophageal cancer tissues were 58.33%,63.33%,respectively,which were higher than the expression of specimens of normal esophageal epithelium（0.00%,0.00%）（P〈0.05）.The expression of CXCL12 and VEGF in esophageal cancer were related to the depth of invasion,TNM stage and lymph node metastasis（P〈0.05）,which had no significant statistical difference with patient′s age,sex and esophageal tumor site,tumor length.The expression of CXCL12 was positively correlated with the expression of VEGF in esophageal cancer（R=0.479,P〈0.05）.Conclusion The expression of CXCL12 and VEGF are significantly increased in esophageal cancer tissues,which may have a synergistic effect in esophageal squamous cell carcinoma invasion and lymph node metastasis.
出处
《安徽医科大学学报》
CAS
北大核心
2010年第2期165-168,共4页
Acta Universitatis Medicinalis Anhui
关键词
食管肿瘤
免疫组织化学
血管内皮生长因子类
癌
鳞状细胞
esophageal neoplasms
immunohistochemistry
vascular endothelial growth factor
carcinoma
squamous cell
