摘要
目的观察抗结核性药物所致肝损害的临床特点，总结其预防和治疗措施。方法对我院2006年4月～2009年4月318例抗结核治疗患者的肝功能损害情况进行回顾性分析。结果318例患者在治疗过程中有247例出现不同程度的肝功能损害。轻度损害者加用保肝治疗，患者肝功能可恢复正常。中、重度患者改用或停用肝毒性药物，并加保肝治疗，大部分患者肝功能可恢复，但仍有部分患者肝功能进行性恶化，导致抗结核治疗终止。结论加强对抗结核治疗患者肝功能损伤的观察，并在早期加以保肝治疗，这是保证抗结核治疗顺利完成的重要措施。
Objective To observe the clinical features of cases with anti-tuberculosis drug-induced liver function impairment and sum up the prevention and treatment measures. Methods Three-hundred and eighteen eases with anti-tuberculosis treatment were retrospectively analyzed. Results Two-hundred and forty-seven cases suffered from varying degrees of liver dysfunction. Patients with mild dysfunction were dealt with liver protection therapies and their liver functions returned to normal. While those with moderate to severe liver dysfunction were treated by changing or stopping liver toxic drugs and strengthening the liver protection therapies, but not all of their liver functions returned to normal, and some even had to stop anti-tuberculosis treatment. Conclusion Being alert to the liver impairments in patients with antituberculosis treatment and strengthening their liver protection are important for the anti-tuberculosis treatment.
出处
《西部医学》
2010年第5期889-890,共2页
Medical Journal of West China
关键词
抗结核
肝功能
治疗
Anti-tuberculosis
Liver function
Treatment
