摘要
结核病是一种与营养不良有关的传染性疾病.营养不良可影响肝脏合成血清白蛋白功能,从而诱发或加重药物性肝功能损伤（简称“肝损伤”）.抗结核药物可引起药物性肝损伤,在营养不良的状况下,肝血流灌注障碍,肝血流量减少,使药物清除率下降,加重药物性肝损伤.因此,在结核病合并营养不良的患者治疗过程中,应该在积极抗结核治疗的同时加强营养支持治疗;改善结核病患者的营养状况,是减少抗结核药物性肝损伤,使抗结核治疗顺利进行的重要保证.
Tuberculosis is a contagious disease related to malnutrition. Malnutrition can affect synthesis of serum albumin in liver, and also induce or exacerbate drug-induced liver injury. Under the conditions of malnutri tion, drug-induced liver injury caused by anti tuberculosis drugs may lead to hepatic perfusion disorders, reduce the hepatic blood flow and the clearance of drugs, and exacerbate this disease. Therefore, during the treatment for pa- tients with tuberculosis combined with malnutrition, anti-tuberculosis treatment and improvement the nutritional status, should be implemented actively. Improvement of the nutritional status in patients with tuberculosis is very important to reduce drug induced liver injury and to guarantee anti-tuberculosis treatment Derformed ~mncnhlv
出处
《中国防痨杂志》
CAS
2014年第1期64-66,共3页
Chinese Journal of Antituberculosis
基金
广州市医药卫生科技项目（20131A011080）
关键词
结核
营养不良
抗结核药
肝炎
中毒性
危险因素
Tuberculosis
Malnutrition
Antitubercular agents
Hepatitis, toxic
Risk factors
