摘要
目的评价盐酸氨基葡萄糖治疗骨关节炎的疗效及安全性。方法采用随机对照临床研究方法,将128例膝骨关节炎患者随机分为2组。试验组64例,给与口服盐酸氨基葡萄糖一次750mg,一天2次,6周,停药3个月后重复治疗一个疗程;对照组64例,给与口服硫酸氨基葡萄糖一次500mg,一天3次,6周,停药3个月后重复治疗一个疗程。采用Lequesne指数作为疗效评定指标。观察用药前、用药1疗程和用药2疗程后膝关节症状:休息痛、运动痛、压痛、肿胀、晨僵及行走能力的改善,记录不良反应及实验室检查指标。结果试验组用药1疗程、2疗程后Lequesne指数(3.5±1.7,3.3±1.8)与用药前(9.5±1.8)相比明显下降(P<0.05),治疗1疗程、2疗程后症状改善率分别为90%、91.6%。对照组用药1疗程、2疗程后Lequesne指数(3.4±1.9,3.3±1.6)与用药前(9.5±1.6)相比明显下降(P<0.05),治疗1疗程、2疗程后症状改善率分别为90.3%、91.9%。两组间Lequesne指数下降及症状改善率相比无显著性差异。试验组和对照组的不良反应发生率分别为5%和6.5%,主要表现为轻度胃肠部不适。结论盐酸氨基葡萄糖可以明显缓解骨关节炎症状,改善关节功能,是一种安全有效的药物,其治疗效果与硫酸氨基葡萄糖相当。
Objective To evaluate the efficacy and safety of glucosamine hydrochloride in the treatment of knee osteoarthritis. Methods A randomized controlled clinical trial of glucosamine hydrochloride versus glucosamine sulfate was conducted. 128 patients sustaining knee osteoarthritis were randomized into 2 groups. 64 patients were in the test group, and 64 were in the control group. Patients in the test group orally took glucosamine hydrochloride 750mg each time, twice a day for 6 weeks, and resumed this course of treatment 3 months after the first course. Patients in the controll group orally took glucosamine sulfate 500mg each time, 3 times a day for 6 weeks, and resumed this course of treatment 3 months after the first course. Lequesne index was used as evaluation indicator. The following symptoms were observed before the medication, after the first course of treatment and after the second course. They were rest pain, kinesialgia, pressure pain, swelling, morning stiffness, and the improvement of walking ability. Side-effect and lab results were recorded. Results the Lequesne index of the test group significantly decreased after the first and the second course of treatment（3.5±1.7, P〈0.05; 3.3±1.8 P〈0.05）. The symptomatic improvement rate of the test group was 90% and 91.6% in the first and second course of treatment respectively. The Lequesne index of the control group also significantly decreased after the first and the second course of treatment （3.4±1.9, P〈0.05, 3.3±1.6 P〈0.05）. The symptomatic improvement rate of control group was 90.3% and 91.9% in the first and second course of treatment respectively. There was no significant difference between the decrease of Lequesne index and the symptomatic improvement rate in both groups. The adverse effect incidence rate was 5% in the test group and 6.5% in the control group, which was mainly stomach discomfort. Conclusions Glucosamine hydrochloride can effectively improve the osteoarthritis symptoms, and better the joint functions. It is a safe and e
出处
《中国骨肿瘤骨病》
2010年第2期160-163,共4页
Chinse Journal Of Bone Tumor And Bone Disease
