摘要
目的研究肚痛健胃整肠丸对胃黏膜的保护作用及其对肠道菌群的调节功能。方法采用无水乙醇致大鼠胃黏膜损伤模型、吲哚美辛致大鼠胃黏膜损伤模型和冰醋酸诱发大鼠胃溃疡模型等考察肚痛健胃整肠丸对胃黏膜的辅助保护作用;采用林可霉素制备小鼠肠道菌群失调模型,观察肚痛健胃整肠丸对肠道菌群(乳酸杆菌、双歧杆菌、肠球菌、产气荚膜梭菌和大肠埃希菌)的调节作用。结果肚痛健胃整肠丸可减轻乙醇和吲哚美辛所致大鼠急性胃黏膜损伤,对醋酸诱发大鼠胃溃疡亦有明显抑制作用,可增加肠道微生态失调小鼠体质量;增加肠道微生态失调小鼠模型乳酸杆菌、双歧杆菌数量,减少肠球菌、大肠埃希菌数量。结论肚痛健胃整肠丸具有保护胃黏膜作用和调节肠道菌群功效。
ObjectiveTo investigate the adjustment function of intestinal bacteria and protective effect on stomach-mucosa of dutong jianwei zhengchang pills. MethodsStomach-mucosa injury was induced in rats by ethanol, indomethacin,glacial acetic acid, respectively and the mucosal protecction by dutong jianwei zhengchang pills was studied. Intestinal bacteria function incoordination in mice was induced by lincomycin and adjusting function of intestinal bacteria（lactobacillus, bifidobacterium, enterococcus,iclostridium perfringensn and E. coli）by dutong jianwei zhengchang pills was evaluated. ResultsDutong jianwei zhengchang pills relieved stomach-musoca injuries caused by various agents, increased the body weight of mice with intestinal function incoordination. It raised the amount of lactobacillus and bifidobacterium, decreased iclostridium perfringensn and E. coli. ConclusionDutong jianwei zhengchang pills have protective effect to stomach-mucosa and adjustment function of intestinal bacteria.
出处
《医药导报》
CAS
2010年第5期591-594,共4页
Herald of Medicine
关键词
肚痛健胃整肠丸
胃黏膜
肠道菌群
Dutong jianwei zhengchang pills
Stomach-musoca
Intestinal bacteria
