摘要
目的探讨糖尿病与胰腺癌的关系,高血糖对胰腺癌组织内神经的影响。方法采用病例对照研究对我院1999年1月至2008年3月诊治的胰腺癌患者513例进行回顾性研究,分为血糖升高组和正常血糖组,进行各项指标比较;并对手术切除组织标本进行神经相关指标免疫组化染色,观察其表达差异。结果各项指标中,高血糖组更容易出现精神差(P<0.05);有糖尿病史的患者中,血糖得到控制的手术切除率和疼痛出现率明显增高(P<0.05);免疫组化表现,两组亦有差异。结论明确有糖尿病史的胰腺癌患者,积极控制血糖有利于提高根治性手术率,高血糖可使胰腺癌神经发生改变,可能参与了神经浸润的发生。
Objective To explore the relationship between diabetes and pancreatic cancer and the role of hyperglycemia in the nerves distributed in pancreatic cancer.Methods We made a retrospective case control study of 513 pancreatic cancer patients in our hospital between January 1999 and March 2008.They were divided into euglycemia group and hyperglycaemia group,and various indexes were compared between them.Expressions of protein gene product 9.5（PGP9.5） and myelin P0 protein（MPP） were analyzed by immunohistochemistry in formalin-fixed radical cured pancreatic cancer specimens from 81 pancreatic cancer cases and 10 normal pancreas tissue cases as controls.Results More cases had the symptom of weariness in hyperglycaemia group compared with euglycemia group（P〈0.05）.The frequency of radical operation and pain was higher when the level of blood glucose was controlled within the normal range in the cases with the history of diabetes mellitus（DM）（P〈0.05）.The frequency of strong PGP9.5 staining was significantly higher in hyperglycaemia group than in euglycemia group and normal control group（P〈0.05） whereas the expression of MPP was the opposite among the three groups（P〈0.05）.Conclusion Controlling blood glucose within the normal level can help increase the rate of radical operation in pancreatic cancer cases with hyperglycaemia.Hyperglycemia can alter the nerve fibers in pancreatic cancer,which may effect the perineural infiltration in pancreatic cancer.
出处
《西安交通大学学报（医学版）》
CAS
CSCD
北大核心
2010年第3期279-282,共4页
Journal of Xi’an Jiaotong University（Medical Sciences）
关键词
胰腺癌
糖尿病
神经浸润
pancreatic cancer
diabetes mellitus
perineural infiltration
