摘要
目的观察血清瘦素(leptin)在结肠癌患者中的变化及其意义。方法研究分结肠癌组(40例)、溃疡性结肠炎组(30例)及正常对照组(40例),采用全自动生化分析仪检测各组血清总胆固醇(TC)、甘油三酯(TG)等生化指标并应用放射免疫分析法及ELISA法检测血清瘦素、癌胚抗原(CEA)及血管内皮生长因子(VEGF)。结果与正常对照组比,结肠癌组血清TC、TG、瘦素、CEA、VEGF含量升高(P<0.05),溃疡性结肠炎组血清TG、瘦素含量升高(P<0.05);与结肠癌组比,溃疡性结肠炎组血清瘦素、CEA、VEGF含量降低(P<0.05),TC、TG含量无明显改变。血清瘦素与TC、TG、VEGF呈正相关,而与CEA无相关性。结论血清瘦素可能通过VEGF发挥其对结肠癌的促进作用。
Objective To determine the serum leptin levels in patients with colon tumor.Methods The serum levels of TC and TG were measured by immunoseparation assay and the serum levels of leptin,CEA and VEGF were determined by ELISA method in 40 patients with colon tumor,30 patients with ulcer colitis and 40 healthy subjects.Results The serum levels of TC,TG,leptin,CEA and VEGF in colon tumor,and the serum levels of TG and leptin in ulcer colitis were significantly higher than those in healthy controls（P0.05）.Serum leptin levels were positively correlated with TC,TG,and VEGF levels,but not correlated with CEA levels.Conclusion The expression of serum leptin may be related to the oncogenesis and development of colon cancer.
出处
《实用肿瘤杂志》
CAS
北大核心
2010年第2期177-179,共3页
Journal of Practical Oncology
