摘要
娑罗子为七叶树科植物欧洲七叶树(Aesculus hippocastannum)、日本七叶树(Aesculus turbinata Blume)和中国天师栗(Aesculus Wilsonii Rehd)的果实或种子。欧洲七叶树,又名欧马栗(horse chestnut),其种子和幼枝的外皮可入药,在欧洲应用广泛,早在18世纪即用于解热,19世纪后期可用于治疗痔疮。七叶皂苷是从娑罗子(七叶树种子)中提取的主要活性成分,属于三萜皂苷类药物。它具有抗渗、消肿、改善血液循环、增加静脉张力、抑制胃排空、清除活性氧和抗肿瘤作用。临床上可广泛应用于慢性静脉功能不全,痔疮、水肿、哮喘等。本文对七叶皂苷的药理作用及其临床应用进行综述。
The seeds of Aesculus hippocastannum, Aesculus turbinata Blume and Aesculus wilsonii Rehd are the resource of the traditional chinese medicine Semen Aesculi. The seeds and the bark of young branches ofAesculus hippocastanum （the horse chest-nut tree） congeneric plant ofAesculus chinesis Bunge are also widely used as medicines in Europe. Dating from the early 18th century some reports have indicated therapeutic properties for horse chestnut. These have ranged from anti-fever to, at the end of the 19th century, anti haemorrhoidal properties. Aescin is the main active constituent from the horse chestnut seed extract, a complex mixture of chemically very similar compounds known as triterpenoid saponins. A number of reports have indicated therapeutic properties for aescin possess anti-inflammatory, antiedematous, capillary-protective properties, accrescence intravenous tension, suppress gastric emptying, eliminate active orygen and anti-tumbor and have shown satisfactory evidence for clinically significant activity in chronic venous insufficiency （CVI）, haemorrhoids, asthma and oedema. In this paper, the pharmacological effects Aescin and its clinical application were reviewed.
出处
《现代生物医学进展》
CAS
2010年第5期957-960,共4页
Progress in Modern Biomedicine
基金
国家自然科学基金项目资助(30901834)
关键词
七叶皂苷
药理作用
临床应用
aescin
pharmacological effects
clinical application
