摘要
支气管哮喘（简称哮喘）是一种气道慢性炎症，持续的气道炎症导致气道重塑、不完全可逆的气流受限和进行性的肺功能受损。平滑肌细胞的增殖（包括增生和肥大）是哮喘气道重塑的特征性改变，是哮喘气道反应性和严重程度相关的重要因素之一。转化生长因子β（TGF-β）能够诱导分化、炎症、增生以及凋亡等多种细胞反应，促进平滑肌细胞的增生、肥大和迁移，在气道重塑中发挥重要作用。减少TGF-β的产生以及控制TGF—β的效应有利于对慢性哮喘气道重塑的干预治疗。
Bronchial asthma（asthma） is a chronic inflammatory disease. Persistent inflammation in airway tissues may lead to airway remodeling,not fully reversible airway obstruction and progressive loss of lung function. Airway smooth muscle proliferation（including hyperplasia and hypertrophy）is the most l^rominent feature of airway remodeling in asthma,and it also is one of most important factors related to asthma airway responsiveness and the severity of asthma. Transforming growth factor-beta（TGF-~）plays important roles in asthma airway remodeling. Multiple cellular responses including differentiation, apoptosis and proliferation can he induced by TGF-β. TGF-β can induce airway smooth muscle hyperplasia,hypertrophy and migration. Reduction of TGF-β and inhibition of TGF-β activity would be beneficial for the development of therapeutic intervention in chronic asthma airway remodeling.
出处
《国际呼吸杂志》
2010年第3期169-172,共4页
International Journal of Respiration
关键词
支气管哮喘
气道重塑
转化生长因子Β
平滑肌细胞增殖
信号转导途径
Bronchial asthma
Airway remodeling
Transforming growth factor-β
Smooth muscle proliferation
Signal transduction pathway
