摘要
与抗体相比,核酸适体作为生物传感器的敏感元件具有一定的优势。核酸适体的出现为生物分析方法和传感器的设计开辟了新思路。基于核酸适体的电化学传感器集成了适体和电化学传感两方面的优势,成为近年来的研究热点。各种新颖的设计思路不断涌现,使电化学核酸适体传感器的性能不断得到改善,来解决分析应用中所面临的一些问题。该文就响应原理和存在的问题讨论如何设计一个性能优异的电化学核酸适体传感器。
Aptamers possess some outstanding advantages compared to antibodies when used as sensing elements for biosensor.The emergence of aptamers opens a new way for bioanalysis and sensor designing.The coupling of aptamer recognition element with various electrochemical transducers built the new generation of electrochemical aptasensors that combines the advantages of both aptamers and electrosensors.The investigations on this type of aptasensors have drawn considerable interests in recent years.Versatile sensor designing strategies have emerged to improve the performance of electrochemical aptasensors to solve some of the analytical application problems facing.The following content discuss with the principle and problems in how to design an electrochemical aptasensor with good performance.
出处
《化学传感器》
CAS
2010年第1期3-12,共10页
Chemical Sensors
