摘要
目的:探讨更年期妇女潮热与β-内啡肽(β-EP)、雌二醇(E2)、促黄体生成激素(LH)的相关性。方法:采用病例对照方法,对58例更年期妇女(其中30例有潮热、28例无潮热)和25例育龄妇女,分别测定血浆β-EP、血清E2及LH的含量。结果:①更年期有潮热妇女与无潮热和育龄妇女比较,β-EP水平降低,LH水平升高,差异均有统计学意义(P<0.05),更年期有潮热与无潮热妇女血清E2水平比较差异无统计学意义(P>0.05);②E2与β-EP呈正相关(r=0.315,P<0.05),β-EP与LH呈负相关(r=-0.391,P<0.01),潮热程度与β-EP呈正相关(rs=0.518,P<0.01),与E2相关程度不显著(P>0.05)。结论:更年期妇女潮热症状与血循环中雌二醇下降、LH升高、β-EP浓度变化有关,潮热严重程度与血浆β-EP水平有关。
Objective： To explore the correlation between hot flushes and β - endoqhin （ β - EP） , estradiol, luteinizing hormone （LH） in climacteric women. Methods： The levels of plasma β -EP, serum estradiol and LH in 58 climacteric women （30 with hot flushes and 28 without hot flushes） and 25 healthy women of child - bearing age were detected. Results ： Compared to climacteric women without hot flushes and healthy women of child - bearing age, the level of β - EP decreased and the level of LH increased in women with hot flushes, there was significant difference （ P 〈 0. 05 ）, there was no significant difference in level of serum estradiol between women with hot flushes and without hot flushes （ P 〉 0. 05 ） . There was a positive correlation between estradiol and β - EP （ γ = 0. 315, P 〈 0. 05 ）, there was a negative correlation between β - EP and LH （ γ = - 0. 391, P 〈 0. 01 ）, there was a positive correlation between degree of hot flushes and β, - EP （γs = 0. 518, P 〈 0. 01 ） , but there was no correlation between degree of hot flushes and estradiol （ P 〉 0. 05 ） . Conclusion ： The occurrence of climacteric hot flushes is related to the decline of serum estradiol, increase of LH and the change of plasma β - EP level. The degree of hot flushes is related to level of plasma β - EP.
出处
《中国妇幼保健》
CAS
北大核心
2010年第12期1676-1678,共3页
Maternal and Child Health Care of China
