摘要
应用层粘连蛋白和Ⅳ型胶原的单克隆抗体对中度至重度成人慢性牙周炎龈上皮基底膜进行免疫组化研究，并结合电镜和ＰＡＳ技术加以分析。结果发现，正常时龈上皮基底膜呈连续均匀的带状分布，而炎症时则失去正常外观，出现多个散在的微小断裂，甚至个别上皮钉突基底膜缺失。
The major components of basement membrane including laminin and type IV collogen were studied by immunohistochemistry in 20 gingival specimens from patients with morderate to severe adult periodontitis and 10 normal gingival specimens combing with electron microscopic and PAS analysis.The results showed that laminin and type IV collogen were both present and stained with a continuous liner pattern in oral sulcular epithelium of the normal gingivae, while the pocket epithelial alterations of the periodontitis occured, which included thining, interruption, partial or complete absence of basement membrane involving one or more rete pegs and fragmentations.All these alterations may play an important role in the pathogenesis of adult periodontitis.
出处
《华西口腔医学杂志》
CAS
CSCD
北大核心
1998年第2期114-116,I005,共4页
West China Journal of Stomatology
关键词
牙周炎
基底膜
层粘连蛋白
Ⅳ型胶原
\ immunohistochemistry\ \ basement membrane\ \ laminin\ \ type IV collogen\ \ periodontitis
