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奥沙利铂联合氟尿嘧啶和亚叶酸钙治疗局部进展期胃癌的临床研究 被引量:9

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摘要 目的观察奥沙利铂联合氟尿嘧啶和亚叶酸钙(FOLFOX)方案术前进行新辅助化疗对局部进展期胃癌的临床疗效及毒副反应。方法31例局部进展期胃癌(中晚期)胃癌患者行奥沙利铂联合氟尿嘧啶和亚叶酸钙方案的新辅助化疗,并观察临床症状、体征、病理变化和影像学变化。结果临床有效率80.6%,组织病理学有效率61.3%,影像学肿块有效缩小率74.2%,肿块R0切除率74.2%。结论奥沙利铂联合氟尿嘧啶和亚叶酸钙新辅助化疗方案耐受性好,能提高局部进展期胃癌的R0切除率,改善预后,提高肿瘤综合治疗效果,值得推广。
作者 黄珠兰
出处 《齐齐哈尔医学院学报》 2010年第2期219-220,共2页 Journal of Qiqihar Medical University
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参考文献12

  • 1San W,Haller DG.Recent advances in the treatment of gastric cancer[J].Drug,2001,61(11):1 545-1 551. 被引量:1
  • 2金懋林.新辅助化疗在胃癌治疗中的作用[J].外科理论与实践,2000,5(3):140-142. 被引量:24
  • 3陈国玉.进展期胃癌的新辅助化疗[J].临床外科杂志,2005,13(8):476-478. 被引量:23
  • 4Elliot Newman E,Marcus SG,Potmesil M,et al.Neoadjuvant chemotherapy with CPT-11 and cisplatin downstages locally advanced gastric cancer[J].J Gastrointest Surg,2002,6(2):212-223. 被引量:1
  • 5John E,Niederhuber MD.Neoadjuvant therapy[J].Ann Surg,1999,229(3):309-312. 被引量:1
  • 6Cvitkovic E.A historical perspective on oxalipatin:rethinking the role of platinum compounds and learning from nearmisses[J].Sem in Oncol,1998,25(2):1-3. 被引量:1
  • 7Peteux M,Louret C,Bekradda M,et al.Oxalipatin for the treatment of advanced colorectal cancer; future directions[J].Sem in Oncol,1998,25(2):47-53. 被引量:1
  • 8Adida C,Crotty PL,McGrath J,et al.Developmentally regulated expression of the novel cancer anti-apoptosis gene survivin in human and mouse defferentiation[J].Am J Pathol,1998,152(1):43. 被引量:1
  • 9Yoshida H,Ishiko O,Sumi T,et al.Survivin,bcl-2 and matriix metalloproteinase-2 enhance progression of clear cell and seroustype ovarian carcinomas[J].lnt J Oncol,2001,19(3):537. 被引量:1
  • 10Lowy AM,Mansfield PF.Response to neoadjuvant chemo therapy best predicts survival after curative resection of gastric cancer[J].Ann Surg,1999,229(3):303-308. 被引量:1

二级参考文献12

  • 1Fujii M,Kochi M,Mochizuki F.Significance of neoadjuvant chemotherapy for gastric cancer [J].Gan To Kagaku Ryoho,2000,27(11):2028-2032. 被引量:1
  • 2Shchepotin IB,Chorny V,Hanfelt J,et al.Palliative superselective intraarterial chemotherapy for advanced nonresectable gastric cancer [J].J Gastrointest Surg,1999,3(4):426-431. 被引量:1
  • 3Lowy AM,Mansfield PF,Leach SD,et al.Response to neoadjuvant chemotherapy best predicts survival after curative resection of gastric cancer [J].Ann Surg,1999,229(3):303-308. 被引量:1
  • 4Ott K,Sendler A,Becker K,et al.Neoadjuvant chemotherapy with cisplatin,5-FU,and leucovorin(PLF) in locally advancel gastric cancer:a prospective phase Ⅱ study [J].Gastric Cancer,2003,6(3):159-167. 被引量:1
  • 5Persiani R,D'Ugo D,Rausei S,et al.Prognostic indicators in locally advanced gastric cancer(LAGC) treated with preoperative chemotherapy and D2-gastrectomy [J].J Surg Oncol,2005,89(4):227-236. 被引量:1
  • 6Cascinu S,Graziano F,Barni S,et al.A phase Ⅱ study of sequential chemotherapy with docetaxel after the weekly PELF regimen in advanced gastric cancer. A report from the Italian group for the study of digstive tract cancer [J].Br J Cancer,2001,84(4):470-474. 被引量:1
  • 7San W,Haller DG.Recent advances in the treatment of gastric cancer [J].Drug,2001,61(11):1545-1551. 被引量:1
  • 8Crookes P,Leichman CG,Leichman,et al.Systemic chemotherapy for gastric carcinoma followed by postoperative intraperitoneal therapy:a final report[J].Cancer,1997,79(9):1767-1775. 被引量:1
  • 9Elliot Newman E,Marcus SG,Potmesil M,et al.Neoadjuvant chemotherapy with CPT-11 and cisplatin downstages locally advanced gastric cancer [J].J Gastrointest Surg,2002,6(2):212-223. 被引量:1
  • 10Kollmannsberger C,Quietzsch D,Haag C,et al.A phase Ⅱ study of paclitaxel,weekly,24-hour continuous infusion 5-fluorouracil,folinic acid and cisplatin in patients with advanced gastric cancer [J].Br J Cancer,2000,83(4):458-462. 被引量:1

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