摘要
目的 探讨思他宁在不能手术治疗的胃肠道肿瘤所致恶性肠梗阻治疗中的作用。方法 2002年1月至2006年6月,将62例胃肠道恶性肿瘤所致肠梗阻随机分为常规治疗对照组30例和思他宁治疗组32例,治疗组给予常规治疗加用思他宁（每天6mg静脉滴注,维持24h）3~12天,比较两组治疗前后的疗效。结果 治疗组临床症状较对照组明显改善,腹痛、腹胀缓解率分别为84.4%、57.6%（P〈0.05）;肛门恢复排气排便比率分别为62.1%、25.0%（P〈0.01）;胃肠平均减压量明显少于对照组,分别为（216±158）ml/d、（522±184）ml/d（P〈0.001）,81.3%的患者腹部平片显示肠管积气积液减少消失,生活质量明显改善,KPS分值分别为57±7、45±9（P〈0.01）。结论 在常规治疗的基础上,应用思他宁治疗胃肠道肿瘤所致恶性肠梗阻,能明显改善患者的不适症状和生活质量。
Objective To investigate the effectiveness of Stilamin in malignant bowel obstruction（MBO） due to inoperable gastrointestinal carcinoma. Methods From Jan. 2002 to Jun. 2006,62 patients with MBO clue to inoperable gastrointestinal carcinoma were randomly divided into two groups： routine therapy group （control group 30 patients） and Stilamin group （32 patients）. Stilamin group received routine therapy combined with Stilamin （6mg/d） by 24 hours continuous infusion for three to twelve days. The effectiveness was observed and compared between the two groups. Results 3 days after treatment, the clinical symptoms of abdominal distention and abdominal pain were relieved significantly in Stilamin group compared with the control group （84.4% and 57.6% ） （P 〈 0.05 ）. The exhaust of anus was more earlier（62.1% and 25.6% ）（ P 〈 0.05 ）. The average volume of gastroenteral decompression reduced more rapidly [ （216±158） ml/d and（522 ± 184） ml/d] （P 〈0.001 ）. Smaller and less fluid - air in the intestinal and in the colon at the 81.3% of patients plain abdominal radiography were observed in stilamin group. Quality of life, evaluated with Karnofsky score （57±7 and 45 ±9） （P 〈 0.01 ）, was improved significantly. Conclusion The administration of Stilamin combined with routine treatment,is effective in the management of MBO. It can effectively relieve the symptoms of MBO and improve the quality of life in patients.
出处
《实用癌症杂志》
2007年第2期188-190,共3页
The Practical Journal of Cancer
关键词
生长抑素
胃肠道肿瘤
肠梗阻
疗效
Somatostatin
Gastrointestinal carcinoma
Bowel obstruction
Effect
