摘要
目的:研究左乙拉西坦治疗儿童癫癎疗效达完全控制及其影响因素,为临床合理使用左乙拉西坦,使其效果最大化提供依据。方法:采用前瞻性研究,按纳入及排除标准纳入病例;疗程≥3个月,统计完全控制率;对完全控制组和非完全控制组患者进行不同发作类型、治疗方案、年龄及病因等对照研究。结果:共纳入癫癎患儿110例,其中完全控制56例(50.9%)。不同发作类型、病因及不同治疗方案的完全控制率比较差异有统计学意义(P<0.05)。结论:左乙拉西坦治疗儿童癫癎有较高的完全控制率,完全控制率与发作类型、治疗方案及病因有关。
Aim： To study the efficiency of levetiracetam in epilepsy therapy for seizure free in children and the impact factors. Methods： 110 children with epilepy which accorded to the standards were brought into, and accepted levetiracetam therapy for over 3 months. The starting dose of 10 mg.kg-1.d-1 was increased with one week steps of 10 mg.kg-1.d-1, up to a minimum effective dose. The seizure free rate were recorded and compared between the different seizure types, treatments, ages and etiologies. Results： Among 110 patients, 56（50.9%） children had been seizure-free. The rates of seizure free between different seizure types, treatments （monotherapy or adjunctive therapy） and etiologies have significant differences（P〈0.05）. Conclusion： Levetiracetam is effective and has high rate of seizure free in children＇s epilepsy therapy, and the rates of seizure free are influenced by seizure types, treatments and etiologies.
出处
《中国临床神经科学》
2010年第2期152-155,共4页
Chinese Journal of Clinical Neurosciences
关键词
儿童
癫痫
左乙拉西坦
children
epilepsy
levetiracetam
