摘要
目的:研究探讨Survivin表达与结肠癌组织分化、TNM分期的关系。方法:采用免疫组化方法检测117例结肠癌患者手术病理标本中Survivin的表达情况,并根据患者组织分化程度、TNM分期分类统计Survivin的表达情况。结果:高分化结肠癌标本Survivin表达阳性率为51.0%,明显低于中低分化结肠癌标本的100%(P<0.05)。Ⅰ、Ⅱ期结肠癌标本Survivin表达阳性率为59.1%,明显低于Ⅲ、Ⅳ期结肠癌标本的98.0%(P<0.05)。结论:Survivin的表达阳性率与结肠癌的分化程度、TNM分期密切相关,临床可通过检测结肠癌病理标本中Survivin的表达水平,作为判断预后的生物学指标。
Objective To study the expression of survivin in colon-carcinoma tissue and its correlation with degree of tumor differentiation and TNM stage in patients with colonic carcinoma. Methods Immunohistochemistry method was applied to detect the survivin expression in surgical specimens from 117 patients with colonic carcinoma,and the results were analyzed statistically with reference to the degree of tumor differentiation and TNM stage. Results The positive rate of survivin expression in well differentiated colon carcinoma specimens was 51.0%,being significantly lower than that in poorly differentiated specimens (100%,P0.05). On the other hand,the positive rate of survivin in colon carcinoma specimens of TNM and Ⅱ stages was 59.1%,also significantly lower than that of Ⅲ,Ⅳ stage specimens (98.0%,P0.05). Conclusion The positive rate of survivin expression was closely related with degree of tumor differentiation and TNM stage. Survivin expression in colon carcinoma specimens might be used as an indicator for prognosis prediction.
出处
《放射免疫学杂志》
CAS
2010年第2期188-189,共2页
Journal of Radioimmanology
关键词
结肠癌
生存素
组织分化
TNM分期
colon carcinoma
survivin
histologic differentiation
TNM stage