摘要
目的探讨急性脑梗死(ACI)患者外周血可溶性E(sE)-选择素、可溶性L(sL)-选择素表达的变化及其与脑梗死体积的关系。方法采用酶联免疫吸附法(ELISA)测定30例ACI患者(发病<72h)血清sE-选择素、sL-选择素的表达水平,并与20名健康者作对照。应用MRI弥散加权成像(DWI)技术测量ACI患者急性期脑梗死的体积,分析其与血清sE-选择素及sL-选择素水平的关系。结果ACI患者血清sE-选择素的表达水平[(10.49±8.70)ng/ml]显著高于正常对照组[(2.93±2.07)ng/ml](P<0.01),而sL-选择素的表达水平[(4.29±2.22)ng/ml]显著低于正常对照组[(6.41±3.28)ng/ml](P<0.01);血清sE-选择素、sL-选择素水平与脑梗死体积不相关。结论ACI患者血清sE-选择素表达上调,sL-选择素表达下调,但都与脑梗死体积不相关,两者可能参与了缺血性脑损伤的病理过程。
Objective To investigate the expression of serum soluble E（sE）-selectin and soluble L（sL）-selectin in patients with acute cerebral infraction（ACI）and its correlation with the volume of the infarction.Methods The expression of serum sE-selectin and sL-selectin in 30 ACI patients（within 72 h after onset）were measured by ELISA,and the results were compared with 20 healthy controls.The volume of the infarction in ACI patients was measured by diffusion weighted imaging（DWI）.The relationship between the infarction volume and the expression of serum sE-selectin and sL-selectin was analyzed.Results The expression of serum sE-selectin in the ACI group [（10.49±8.70）ng/ml] was significantly higher than that in the normal control group [（2.93±2.07）ng/ml]（P〈0.01）,however the expression of sL-selectin [（4.29±2.22）ng/ml] was significantly lower than that in the normal control group [（6.41±3.28）ng/ml]（P〈0.01）.There was no correlation between the expression of sE-selectin,sL-selectin and the volume of infarction.Conclusions The expression of sE-selectin is increased while tsL-selectin is decreased in the patients with ACI,but neither of them are correlated with the infarction volume.It is possible that they are involved in the pathological process of ischemia brain damage.
出处
《临床神经病学杂志》
CAS
北大核心
2010年第1期18-20,共3页
Journal of Clinical Neurology
