摘要
[目的]观察通脉化浊汤对冠心病大鼠血脂的影响,为临床应用提供实验依据。[方法]按体重将大鼠随机分为正常组、模型组、通脉化浊汤高、中、低剂量组、血脂康组共6组,除正常组外,其余5组以维生素D_370 万IU/kg3天内灌胃,饲以高脂饲料,并于给药前一天腹腔注射垂体后叶素30U/kg,描记Ⅱ导心电图,建立冠心病血脂异常模型大鼠,检测TC、TG、HDL、LDL水平。[结果]与模型组相比,通脉化浊汤高、中、低剂量组均可明显降低TC、LDL水平,并提高HDL水平;与血脂康组比较,通脉化浊汤高、中、低剂量组与其无显著差异。[结论]通脉化浊汤可降低冠心病大鼠的血脂,验证和探讨了中医药在冠心病治疗中的作用,为指导临床治疗提供了客观的参考指标。
[ Objective ] To observe the effect of Tongmaihuazhuo decoction on blood lipid in rats with coro- nary atherosclerotic heart disease （CHD） and provide experimental basis for clinical applications. [ Methods ] Rats were divided into six groups：normal group, model group, Tongmaihuazhuo decoction high, middle and low dosage group and Xuezhikang group according to the weight, except for normal group, the other five groups were lavaged into stomach with vitamin D3 70 10000IU/kg in three days, raise high lipid feed, intraperitoneal injec- tion pituitrin 30U/kg before administration day, record lI ECG, establish dyslipidemia in rats models with CHD, test the level of TC, TG, HDL and LDL. r Results ] As compared with model group, the level of TC and LDL was obviously reduced, and the level of HDL was increased in Tongmaihuazhuo decoction high, middle and low dosage groups; As compared with Xuezhikang group, there wasn＇t prominent differences among Tong- maihuazhuo decoction high, middle and low dosage groups. [ Conclusion ] Tongmaihuazhuo decoction can reduce blood lipid in rats with CHD,that validate and discuss the effect of traditional chinese medicine treatment,to guide the clinical treatment provide an objective reference indicator.
出处
《实用中医内科杂志》
2010年第3期23-25,共3页
Journal of Practical Traditional Chinese Internal Medicine
关键词
血脂
冠心病
大鼠
通脉化浊汤
lipid
coronary heart disease
rats
Tongrnaihuazhuo decoction
