摘要
目的:探讨早期低剂量应用短肽类肠内营养液对脓毒症患者血清白细胞介素-6(IL-6)水平的影响。方法:选择34例脓毒症患者,分为治疗组(16例)和对照组(18例)。对照组仅给予抗感染等常规治疗,治疗组同时早期低剂量(1次/d,250 mL/次)给予短肽类肠内营养液治疗1周(治疗过程中治疗组死亡2例,对照组死亡4例,最终纳入疗效分析的2组患者均为14例)。所有患者在入院和治疗第1周内每天留取静脉血,应用ELISA法检测血清IL-6水平。结果:对照组和治疗组患者治疗1周内不同时间血清IL-6水平的差异有统计学意义(F时间=242.067,P<0.001),2组间血清IL-6水平差异有统计学意义(F组间=12.140,P=0.002)。结论:脓毒症患者早期低剂量应用短肽类肠内营养液安全有效,可显著降低血清IL-6水平,有助于脓毒症的控制和患者康复。
Aim ： To investigate the effects of early using of low dose enteral nutrition of short peptide on the serum in- terleukin-6 （IL-6） level in the patients with sepsis. Methods ：A total of 34 patients with sepsis were included in this study and were allocated into treatment group （n = 16） and control group （n = 18 ）. The control group was given anti-infection treatment, and treatment group was additionally given low dose enteral nutrition of short peptide （250 mL/d, for one week） during earlier period（ during the treatment,2 patients died in treatment group,4 cases died in the control group）. Then, the serum IL-6 was measured by ELISA before treatment and every day within one week after treatment. Results： There were significant differences in the level of serum IL-6 within one week after treatment in both groups （ Fume = 242. 067, P 〈 0. 001 ）. Moreover, the level of serum IL-6 in treatment group was significantly lower than that of control group（Fgroup = 12. 140,P = 0. 002） at the same time points. Conclusion：Early low dose using of enteral nutrition of short peptide is safe and effective for the patients with sepsis.
出处
《郑州大学学报（医学版）》
CAS
北大核心
2010年第2期299-301,共3页
Journal of Zhengzhou University(Medical Sciences)
